Scientist I, Translational Sciences

Tr1X (“Trix”) is a biotechnology company focused on engineering cures for autoimmune and inflammatory diseases. The company develops cellular therapies with the potential to cure disease by inducing immune tolerance and restoring homeostasis.

Tr1X has a state-of-the-art technology platform that allows for the scalable generation of engineered living drugs to help patients suffering from debilitating diseases with high unmet medical need. More information can be found at www.tr1x.bio

 

Position Description

Tr1X is seeking an experienced translational researcher to lead the execution of biomarker strategies and correlative studies for early clinical development. The ideal candidate will have proven expertise in bioanalytical strategies for translational proof-of-concept, the ability to work both independently and cross-functionally, apply creative, critical thinking, and generate reproducible data in compliance with regulatory and quality standards to advance Tr1X’s cell therapies. This role involves working with human blood and tissues.

The Impact You’ll Make

• Develop cell-based and molecular bioanalytical methods to interrogate biomarkers of diseases and responses to therapy.
• Execute clinical sample processing and report reproducible results.
• Analyze large amount of data real-time and present findings at team/departmental meetings.
• Evaluate various protocols and methodologies in support of clinical studies.
• Collaborate to ensure seamless transfer of assays and knowledge between teams and personnel.
• Contribute to the development of biomarker and translational strategies.
• Maintain detailed and highly organized documentation of experimental procedures.

The Team – Yes You Belong!

We are building a diverse, bold, agile, and collaborative organization where each team member works closely and communicates respectfully with each other. Tr1X leadership has high expectations for themselves and for you (and so should you!): we expect the company and all its employees to be deeply focused on bringing Tr1X’s therapies to patients at an accelerated pace.

Key attributes to this role include attention to detail, integrity, ability to multitask and to adjust to changing priorities, and a "can do" attitude

You have:

• MS + 4 years of industry experience, or PhD with experience in immunology, cell biology, or related fields, and conducting bioanalytical assay development.

• At least 2 years of experience in a translational/biomarker setting.

• Extensive experience in cell-based assays to characterize T cells, using immunological techniques such as flow cytometry, multi-plexed immunoassays (e.g., MSD, ELISA), and molecular techniques (e.g., RNAseq, Nanostring, dPCR), ideally supporting clinical trial sample analysis.

• Strong ability to critically analyze data, optimize assays independently, and collaborate effectively within a team, with excellent verbal and written communication skills.

• Impeccable documentation skills, including timely electronic lab notebook entries.

• Strong attention to detail to detect experimental anomalies and artifacts.

• Ability to write technical documents such as SOPs and qualification reports, and adhere to SOP specifications without deviation.

• Ability to work under tight deadlines, manage multiple tasks, and drive them to completion.

• The disposition to thrive in a fast-paced startup environment with an agile and organized mindset.

• To be able to safely conduct experiments while wearing required PPE.

Optimally you also have

• Prior experience with assay qualification and/or validation.
• Knowledge of GxP / Quality systems / Compliance Framework for translational activities.
• Prior experience working with partner labs/CROs and transferring assays.

You are

• Legally entitled to work for any employer in the US.

We offer

In addition to a competitive compensation package with stock options, Tr1X offers comprehensive benefits for our employees and their families including:

• Health insurance
• Vision Insurance
• Dental Insurance
• Flexible PTO
• 401k with generous employer match

Salary Range for this position: $120,000-$135,000 depending on experience

At Tr1X we believe that a diverse, open, and inclusive environment and culture is key to our success.  Tr1X will not be influenced in recruitment, hiring, promotion or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Tr1X will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place will not create any implied obligation.