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Co-op, Process Development- Antisense Oligonucleotides (ASOs)

South San Francisco, CA
Why Join Us?
 
Be a hero for our rare disease patients
 
At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won’t go – challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them. 
 
Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth – so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work.
 
If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team.

Position Summary:

ultraimpact – Make a difference for those who need it most

Assist in with small scale synthesis of oligonucleotides (ASO and siRNA).  Responsibilities include operating synthesizer, preparing reagents, running HPLC/LC-MS and maintaining documentation.  The co-op will gain exposure to synthesis and analysis of ASO using automated synthesizer and a variety of analytical and purification instruments. 

Work Model: 

Core Lab & Ops: This role typically requires that the majority of the work be conducted on-site.

Responsibilities:

  • Synthesize, purify, and characterize oligonucleotide constructs. 
  • Record experimental data, procedures and results in Electronic Notebook (ELN). 
  • Performed desalting operations using TFF (tangential flow filtration). 
  • Prepare reagents/buffers for synthesis and characterization methods. 
  • Summarize data in presentations and technical reports. 

Requirements:

  • Graduate or Undergraduate student in, Biochemistry, Chemical Biology program with an emphasis on Organic Chemistry and interest in oligonucleotide synthesis, with at least two years of coursework completed.
    • This is a 6 month co-op, starting July 6, 2026 working full-time (40 hours per week) until December 18, 2026
  • Understanding of organic chemistry, biochemistry, analytical chemistry and oligonucleotide synthesis. 
  • Previous lab experience. At least 3 months of laboratory experience, 6 months prefer. 
  • Strong attention to detail, organization and adherence to safety protocols. 
  • Prior experience with characterization of organic molecules with H/UPLC and LC-MS is a plus. 
  • Knowledge of basic laboratory equipment, pH meter, balances, pipets,
  • ASO and siRNA experience a plus

U.S. Hourly Wage Range: 

  • $23.00-$30.00/hour. The estimated hourly range reflects an anticipated range for this position. The actual hourly wage offered will depend on the candidate’s school year/level.

 

#LI-AJ1     #LI-Onsite

 

 

The typical annual salary range for this full-time position is listed below. This range reflects the characteristics of the job, such as required skills and qualifications and is based on the office location noted in this job posting. The range may also be adjusted based on applicant's geographic location.


This position is eligible for annual bonus and equity incentives. Actual individual pay is determined by demonstrated experience and internal equity alignment.

Pay Range

$1 - $1 USD

 
Full Time employees across the globe enjoy a range of benefits, including, but not limited to:
 
·         Generous vacation time and public holidays observed by the company
·         Volunteer days
·         Long term incentive and Employee stock purchase plans or equivalent offerings
·         Employee wellbeing benefits
·         Fitness reimbursement
·         Tuition sponsoring
·         Professional development plans
 
* Benefits vary by region and country

Ultragenyx Pharmaceutical is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status, and any other status or classification protected by applicable federal, state, and/or local laws. Reasonable accommodation will be provided for all protected statuses or classifications protected by applicable law, including individuals with disabilities, disabled veterans, for pregnancy, childbirth, and related medical conditions, and based on sincerely held religious beliefs. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, you may contact Talent Acquisition by emailing us at talentacquisition@ultragenyx.com.

See our Privacy Policy.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Note to External Recruiters: All candidate activity and open positions are managed strictly through our Human Resources Department. Our Human Resources Department kindly requests that recruiters not contact employees/hiring managers directly in an attempt to solicit business and present candidates. Please note that failure to comply with this request will be a factor in determining a professional relationship with our organization. Submission of unsolicited resumes prior to an agreement set in place between the Human Resources Department and the recruiting agency will not create any implied obligation.  Inquiries on developing a recruiting relationship with us, may be directed to: talentacquisition@ultragenyx.com.

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We are dedicated to fostering an inclusive workplace environment that keeps our teams inspired, empowered, and free to share new ideas—and to better finding solutions that advance the treatment of those living with rare diseases.  We invite you to voluntarily provide demographic information in a confidential survey at the end of this application to assist us in complying with legal requirements and managing our organization. Providing this information is completely optional and it will not be accessible or used by those involved in your hiring or decision-making process. Your response – or decision not to respond, has no impact on your opportunity for employment. Responses to the voluntary self-identification requests will be confidential and securely maintained and only reported in the aggregate in support of the efforts outlined above.

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