Senior/Principal Associate Scientist

About Us

Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform™ as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we.

We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us?

What You’ll Do…

• Work as part of a multifunctional team that include experts in biology, in vitro pharmacology, and ADME
• Generate and maintain cell lines using aseptic techniques to support the cell biology and ADME efforts of our drug discovery programs. You will expand, maintain, and plate a diverse number of mammalian cell lines at any given time (including adherent/suspension immortalized cells, primary cells, stable cell lines, etc.).
• Perform DNA/RNA transfections and viral transductions in a BSL-2 facility to establish in vitro cell models
• Characterize the cell lines you generate, utilizing common techniques such as DNA/RNA isolation, PCR, qRT-PCR, siRNA knockdown, western blot/protein analysis, immunocytochemistry, ELISA, and cell viability/cytotoxicity assays
• Optimize the maintenance conditions of a cell line (such as media selection, passages, freeze-thaws, gene knockdown efficiency, protein-of-interest expression levels, etc.) to enable the highest quality data of downstream applications
• Keep detailed electronic records of both your work and the cellular stocks in liquid nitrogen
• Adhere to safety regulations and good laboratory practices

What You Bring...

• At least a bachelor’s degree in a scientific discipline with 6+ years of relevant laboratory experience
• Demonstrated experience in all steps of cell line generation, from initial genome modifications and clonal selections to cellular characterization and scale up
• Proficiency using machines common in these workflows, such as a multidrop Combi, Apricot, Echo, thermocycler, cell counter, fluorescence microscope, and plate reader systems
• Experience working with many types of mammalian cell lines (experience with iPSCs and iPSC differentiation is a plus)
• Experience with CRISPR-Cas9 workflows, co-culture, organoids, or isolation of primary cells (including hepatocytes) is a plus
• Strong written and oral communication skills and a demonstrated ability to convey information to program team members of varying backgrounds
• Strong time management skills, with the ability to balance experiments for multiple programs and stakeholders
• Ability to troubleshoot, think critically and independently, with excellent attention to detail

More on Valo

Valo Health, LLC (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative diseases. Founded by Flagship Pioneering and headquartered in Lexington, MA. Valo also has offices in New York, NY. To learn more, visit www.valohealth.com.