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Senior Scientist, Cardiometabolic Diseases and Inflammation - Translational Biology

Lexington, Massachusetts, United States

About Us

Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform™ as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we.

We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us?

About the Role... 

Valo is looking for a senior Scientist to play a pivotal role in the lab executing translational biology plans for various drug discovery programs in obesity, type 2 diabetes, and cardiovascular disease for targets that have been identified using Valo’s human-centric Opal computational platform. This position requires expertise in both the biology of cardiometabolic disease and inflammation, a passion for hands on translation of human data driven insights into new therapies, and hands on experience in preclinical drug development programs.  In this role, you will be responsible for designing and executing translational biology plans in collaboration with project team leads to demonstrate in vitro/in vivo correlation including pk/pd assessments, omics profiling of cells and tissues, and discovery/demonstration of cellular and in-vivo biomarkers. This role will be critical to deliver high quality data to build confidence in the translation of disease models and will be responsible for delivering biomarker data packages on various teams and presenting to both internal and external stakeholders. You will collaborate with team leaders, subject matter experts, computational scientists, and tissue engineers. You will participate on project teams as a translational biology subject matter expert and help shape Valo’s preclinical drug development process. 

What You’ll Do…  

  • Perform hands on experiments in the lab and generate data in the laboratory in collaboration with Valo’s other biology experts and/or leveraging CROs to support ongoing drug discovery projects 
  • Execute translational biology strategies to demonstrate in vivo/in vitro correlation in cells and/or animal models 
  • Work with internal teams and external CROs to design and execute in vivo pk/pd, efficacy, and biomarker experiments 
  • Design and execute experiments to identify biomarkers for novel targets and build biomarker strategies suitable for programs of various stages.
  • Build functional biomarker assays to enable interrogation of novel drug targets
  • Generate data with high quality standards and document them in electronic lab notebook 
  • Provide thought leadership and guidance in your expert area of biology, staying abreast of emerging trends and advancements in the field related to tissue and peripheral biomarkers of varying types (safety, predictive, patient segmentation, disease response…) 

What You Bring…  

  • A PhD in Biological Sciences or related field with 5+ years of experience (or MS with 9+ years of experience or BS with 11+ years of experience) and deep expertise in two or more of the following areas: Tissue Inflammation, Cardiovascular immunology, obesity (adipose tissue biology) or liver biology. 
  • Expertise with in vitro human cell systems and ability to work across varying systems (PBMCs, primary tissue cells, organoids) 
  • Experience with in vivo models of human CVM/Obesity (mouse, rat, pig) 
  • Experience working with external vendors/CROs 
  • Experience with drug discovery programs and biomarkers linked to Mechanism of Action 
  • Strong oral and written communication, presentation and interpersonal skills  
  • Experience in collaborating with multidisciplinary teams in preclinical drug development 

You May Also Bring…   

  • Experience with immunology techniques such as flow cytometry, ELISA, and Luminex 
  • Experience generating samples for multi-omics profiling, RNAseq, Metabolomics, and Lipidomics 

More on Valo

Valo Health, LLC (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative diseases. Founded by Flagship Pioneering and headquartered in Lexington, MA. Valo also has offices in New York, NY. To learn more, visit www.valohealth.com.

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