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Senior Scientist, Cardiometabolic Diseases and Inflammation - Translational Biology

Lexington, Massachusetts, United States

About Us

Valo Health is a human-centric, AI-enabled biotechnology company working to make new drugs for patients faster. The company’s Opal Computational Platform transforms drug discovery and development through a unique combination of real-world data, AI, human translational models and predictive chemistry. 

Our talented team of biologists, chemists and engineers, armed with advanced AI/ML tools, work together to break down traditional R&D silos and accelerate the speed and scale of drug discovery and development. 

Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We embrace new ways of learning, solve complex problems and welcome diverse perspectives that can help us advance patient-centric innovation. 

Valo is headquartered in Lexington, MA, with additional offices in New York, NY and Tel Aviv, Israel.  To learn more, visit www.valohealth.com.  

About the Role... 

Valois looking for a senior Scientist to play a pivotal role in the lab executing translational biology plans for various drug discovery programs in obesity, type 2 diabetes, and cardiovascular disease for targets that have been identified using Valo’s human-centric Opal computational platform. This position requires expertise in both the biology of cardiometabolic disease and inflammation, a passion for hands on translation of human data driven insights into new therapies, and hands on experience in preclinical drug development programs.  In this role, you will be responsible for designing and executing translational biology plans in collaboration with project team leads to demonstrate in vitro/in vivo correlation including pk/pd assessments, omics profiling of cells and tissues, and discovery/demonstration of cellular and in-vivo biomarkers. This role will be critical to deliver high quality data to build confidence in the translation of disease models and will be responsible for delivering biomarker data packages on various teams and presenting to both internal and external stakeholders. You will collaborate with team leaders, subject matter experts, computational scientists, and tissue engineers. You will participate on project teams as a translational biology subject matter expert and help shape Valo’s preclinical drug development process. 

What You’ll Do… 

  • Perform hands on experiments in the lab and generate data in the laboratory in collaboration with Valo’s other biology experts and/or leveraging CROs to support ongoing drug discovery projects 
  • Execute translational biology strategies to demonstrate in vivo/in vitro correlation in cells and/or animal models 
  • Work with internal teams and external CROs to design and execute in vivo pk/pd, efficacy, and biomarker experiments 
  • Design and execute experiments to identify biomarkers for novel targets and build biomarker strategies suitable for programs of various stages.
  • Build functional biomarker assays to enable interrogation of novel drug targets
  • Generate data with high quality standards and document them in electronic lab notebook 
  • Provide thought leadership and guidance in your expert area of biology, staying abreast of emerging trends and advancements in the field related to tissue and peripheral biomarkers of varying types (safety, predictive, patient segmentation, disease response…) 

What You Bring… 

  • A PhD in Biological Sciences or related field with 5+ years of experience (or MS with 9+ years of experience or BS with 11+ years of experience) and deep expertise in two or more of the following areas: Tissue Inflammation, Cardiovascular immunology, obesity (adipose tissue biology) or liver biology. 
  • Expertise with in vitro human cell systems and ability to work across varying systems (PBMCs, primary tissue cells, organoids) 
  • Experience with in vivo models of human CVM/Obesity (mouse, rat, pig) 
  • Experience working with external vendors/CROs 
  • Experience with drug discovery programs and biomarkers linked to Mechanism of Action 
  • Strong oral and written communication, presentation and interpersonal skills  
  • Experience in collaborating with multidisciplinary teams in preclinical drug development 

You May Also Bring…   

  • Experience with immunology techniques such as flow cytometry, ELISA, and Luminex 
  • Experience generating samples for multi-omics profiling, RNAseq, Metabolomics, and Lipidomics 

 

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