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Senior Associate Scientist, Translational Biology

Lexington, Massachusetts, United States

About Us

Valo Health is a human-centric, AI-enabled biotechnology company working to make new drugs for patients faster. The company’s Opal Computational Platform transforms drug discovery and development through a unique combination of real-world data, AI, human translational models and predictive chemistry. 

Our talented team of biologists, chemists and engineers, armed with advanced AI/ML tools, work together to break down traditional R&D silos and accelerate the speed and scale of drug discovery and development. 

Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We embrace new ways of learning, solve complex problems and welcome diverse perspectives that can help us advance patient-centric innovation. 

Valo is headquartered in Lexington, MA, with additional offices in New York, NY and Tel Aviv, Israel.  To learn more, visit www.valohealth.com.  

About the Role...

The Senior Associate Scientist will join our Translational Biology team and will be a key player in driving our drug discovery and development efforts in the immunology and inflammation space across both our cardiometabolic and neuroinflammation portfolios. In this role, you will be responsible for driving key data generation efforts with a focus on immune cell assays and utilizing various immune cell systems. You will support target validation, therapeutic lead optimization and drug profiling through the implementation and execution of both cellular and biochemical assays to advance our internal portfolio.

The ideal candidate will have strong immune cell biology and immune cell profiling experience in an industrial setting. Relevant knowledge of various technologies in this space, including experience utilizing flow-cytometry, culture and stimulation of primary immune cells, Cell-sorting, and various techniques to study secretion of inflammatory molecules are key to this role. The successful candidate should demonstrate initiative, ability to tackle complex experiments with some level of independence and be able to thrive in a fast-paced biotechnology work environment including strong communication skills in a cross-functional team setting.

What You’ll Do… 

Your primary areas of responsibility will be:  

  • Perform standard immune cell and inflammation related techniques (e.g. Flow cytometry, cell sorting, ELISA, MSD, Luminex, Western blot, etc...) and maintain laboratory equipment.
  • Plan and execute immunology and inflammation-focused assays to enable target validation and early-stage drug discovery.
  • Culture, maintain and analyze a variety of mammalian cell types including primary immune cells and cell lines.
  • Support the development of cellular and functional assays for our preclinical portfolio.
  • Collaborate with cross-functional teams in a matrixed environment to achieve shared company goals and meet project deadlines.
  • Clearly document experiments, standard operating procedures (SOPs) and all experimental data in an electronic lab notebook (ELN).
  • Communicate and present experimental design and outcomes with project teams.

What You Bring… 

  • BS or MS in Biology, Biochemistry, Immunology, or a related field with 4+ years hands-on lab experience (e.g., biotechfacility such as Broad Institute or Harvard) in industry or academic settings (or equivalent education and experience)
  • Must have minimum 2 years practical experience using multi-color flow cytometry (panel design, instrument operation, data analysis)
  • Must have 3+ years of primary cell work including immune cells
  • Experience with cell sorting for isolation of various immune cell populations
  • Experience growing and maintaining primary immune cells and various mammalian cell lines.
  • Proficiency with at least one of the following: MSD, ELISA, HTRF, or Luminex
  • Strong understanding of Immune cell and inflammatory biology.
  • Experience in design and execution of cellular and biochemical assays.
  • Excellent communication and a willingness to learn new techniques.
  • Ability to work semi-independently to manage priorities and deliver high quality data in a timely manner.

You May Also Bring…

  • Experience with primary monocytes and T-cells including isolation by various methods (positive and negative selection)
  • Experience differentiating and/or skewing primary immune cells
  • Experience with whole blood assays
  • Experience with other biochemical and molecular assays (Western blotting, qPCR, EMSA, etc...)
  • Demonstrated experience working in cross-functional teams.

MA Salary Range

$89,250 - $105,000 USD

Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Valo Health currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Valo Health's good faith estimate as of the date of publication and may be modified in the future.

Please note: At this time, we are only able to consider candidates who currently have permanent US work authorization without the need for immediate or future sponsorship.

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