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Senior Director, Medical Affairs (East)

US - Remote

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 
 
WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:
 
*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.
 
*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
 
*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
 
*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

The Senior Director, Medical Affairs is a senior leadership role responsible for shaping and executing the medical strategy for the company’s vaccine portfolio. This position combines traditional headquarters medical affairs responsibilities with direct oversight of a Medical Science Liaison (MSL) team and engagement with national vaccine recommending bodies and professional organizations. The role ensures scientific excellence, compliance, and alignment with Vaxcyte and public health priorities.

Essential Functions:

  • Contribution to development and implementation of medical affairs strategy for vaccines across the product lifecycle.
  • Provide scientific and clinical expertise to support regulatory submissions, labeling, and safety monitoring.
  • Collaborate with clinical development, regulatory, and commercial teams to ensure consistent scientific messaging.
  • Offer strategic input and thought leadership in publication planning, medical education, and evidence generation initiatives.
  • Monitor emerging data, guidelines, and competitive intelligence to inform strategy.
  • Manage and mentor a team of MSLs, ensuring effective scientific exchange and stakeholder engagement.
  • Align field insights with HQ strategy to drive evidence-based decision-making.
  • Establish performance metrics and professional development pathways for MSLs.
  • Foster collaboration between HQ and field medical teams to ensure seamless execution.
  • Build and maintain relationships with key organizations making vaccine recommendations
  • Represent the company in scientific and policy discussions related to immunization guidelines and vaccine adoption.
  • Provide medical leadership at advisory boards, scientific congresses, and public health forums.
  • Influence vaccine policy and recommendations through evidence-based advocacy.

Requirements: 

  • Advanced degree (PharmD, PhD, MD, or equivalent) in life sciences, immunology, infectious diseases, or public health. A minimum of 12 years progressive experience in medical affairs, including leadership roles.
  • Proven track record in vaccines or infectious disease therapeutic areas.
  • Experience managing MSL teams and integrating field insights into HQ strategy.
  • Strong understanding of immunization policy, public health systems, and regulatory frameworks.
  • Exceptional communication, presentation, and interpersonal skills.
  • Ability to travel up to 70% of the time.
  • Other combinations of education and/or experience may be considered.
Reports to: Vice President, Medical Affairs
 
Location: Remote - US
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $266,000 - $310,000 

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

 

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