Scientist I, Downstream Process Development

San Francisco, California, United States

Vir Biotechnology is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies. 

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.

 

THE OPPORTUNITY

Vir Biotechnology is looking for a collaborative Scientist I to transform downstream bioprocessing. The Downstream Process Development team develops and implements downstream processing methodologies across all modalities that can be easily transferred to the cGMP Manufacturing Team and our CDMO partners. Your primary focus is to participate in the pilot lab build up for Vir’s monoclonal antibody portfolio, execute lab scale experiments to assess platform fit, develop phase appropriate purification processes, and plan, execute, and summarize pilot scale purification batches. Additionally, you will have the opportunity to support tech transfer to cGMP facilities and support late phase process development and process characterization studies with Vir’s CDMO partners.

This role is based in our San Francisco California office with the expectations to be onsite 4 days a week.

WHAT YOU'LL DO

  • Independently design, execute, and analyze lab scale screening, chromatography, and filtration experiments.
  • Perform pilot scale purifications in collaboration with project leads and ensure all relevant information is recorded in a compliant manner. Potential to lead purification pilot scale production batches in the future with managerial responsibilities
  • Summarize lab scale study results, review batch production records, and draft production summary reports.
  • Help create and review of tech transfer protocol, support the technical transfer of downstream unit operations to external manufacturing organizations.
  • Potential to be cross trained for hands-on upstream process development and pilot scale production experience.
  • Support the performance, designs and analyses of late-stage process development, process characterization, and process validation studies.
  • Provide oral project status updates to internal or external shareholders as needed.
  • Align best practices and new technologies with needs of process development and manufacturing departments.

WHO YOU ARE AND WHAT YOU BRING

  • PhD with 0+ years, Master’s with 4+ years, or Bachelor’s with 6+ years of industrial experience in biological sciences, biochemistry, or biochemical/chemical engineering within a biopharmaceutical bioprocess research and development setting
  • Direct monoclonal antibody purification process development experience or pilot scale purification experience is required
  • Direct pilot / cGMP scale purification experience is preferred
  • Experience with technical transfers to external manufacturing partners is preferred
  • Experience with typical modes of chromatography and filtration used in biopharmaceutical manufacturing processes is preferred
  • Good documentation practices (GDP) experience and experience writing standard operating procedures, batch records, and technical reports is preferred

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WHO WE ARE AND WHAT WE OFFER

The expected salary range for this position is $116,500 to $146,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.

Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, childcare reimbursement, education reimbursement, 401K match and lunch each day in the office.

Applicants must currently be authorized to work for any employer in the U.S.  We are unable to sponsor or take over sponsorship of an employment Visa at this time.

All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics. 

This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs.  Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment.

Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

For hires based in the United States, Vir Biotechnology, participates in E-Verify.

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