Senior Director / Director, Program Management

Cambridge, MA

We create shielded stem cell transplants that enable targeted therapies to attack only cancer cells

Every year, thousands of patients with Acute Myeloid Leukemia (AML) and other blood cancers relapse post-transplant with no safe and effective treatment options. Vor Bio’s approach provides the first opportunity to deliver potentially curative treatments post-transplant.

Our novel platform creates a shielded stem cell transplant that is designed to enable multiple modalities and therapies, including Antibody Drug Conjugates (ADCs) and Chimeric Antigen Receptor T (CAR-T) cells, which could potentially be effective against the tumor, but are toxic to normal cells. Vor’s genetically engineered transplant provides a protective shield to the healthy cells and thereby allows the cancer cells to be specifically targeted for destruction.

By shielding healthy cells, Vor Bio is aiming to potentially cure Acute Myeloid Leukemia (AML) and other blood cancers. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine’s greatest challenges.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines

Fellowship: Fostering genuine bonds of collaboration and mentorship

Humility: Acting selflessly by putting the collective mission first

Who We Are Looking For

Vor Bio is recruiting for a seasoned Senior Director/Director of Program Management to lead our clinical stage cell therapy programs. This role demands a strategic, operational, and cross-functional mindset to support our flagship programs, Trem-cel and VCAR33ALLO. Reporting directly to the SVP of Portfolio Strategy and Program Management (PSPM), you will collaborate across research, development, manufacturing, and business functions to establish best practices and strengthen our program management capabilities.

The ideal candidate will be a thought partner for the SVP, thrive in a fast-paced, dynamic, and highly collaborative environment, and have a passion for pioneering first-in-class treatments. You should be ready to embrace new challenges, communicate effectively, think enterprise-wide, and show a strong commitment to advancing our programs from early to late-stage development.

Key Areas of Responsibility

  • Strategic Partnership: Collaborate with the SVP of Portfolio Strategy and Program Management and Program Strategy Team (PST) members to define and execute cross-functional strategies aligned with corporate goals.
  • Operational Excellence: Work with the Program Strategy Team, clinical development functions, and cross-functional sub-teams to translate program strategies into efficient, executable operational plans aligned with timelines and budgets.
  • Program Management: Develop and own program timelines, cross-functional risk mitigation plans, budgets, and Target Product Profiles (TPPs). Drive cross-functional alignment and manage operational priorities.
  • Clinical Support: Partner with the clinical development team, including the CMO, to support ongoing and future clinical studies, ensuring integration and connectivity to overall program planning.
  • Systematic Planning: Establish and own flexible program timelines, including milestones, interdependencies, reporting tools, communication strategies, and contingency planning. Ensure budget support in collaboration with SVP, PSPM, and finance.
  • Team Organization: Plan, schedule, and drive strategic program team meetings, fostering a culture of ownership, accountability, and continuous improvement. Develop high-performing teams. Foster a collaborative team culture where everyone feels highly engaged and confident in sharing their ideas and perspectives.
  • Stakeholder Communication: Effectively communicate with internal stakeholders on the status, goals, risks, and mitigation plans of various programs.
  • Cross-Functional Collaboration: Build healthy and collaborative relationships with functional experts across the organization. Provide cross-functional program management for development and business functions as needed.
  • Strategic Planning: Contribute to organization-wide strategic planning activities, including support for organizational and change management.
  • Decision Facilitation: Support informed decision-making at Vor Bio.
  • Mentorship: Guide and mentor talent at Vor Bio.
  • Function Evolution: Help evaluate and evolve the Portfolio Strategy and Program Management function to set a solid foundation for the design, development, and delivery of transformative therapies to patients.

Qualifications

  • Educational Background: B.S. or M.S. in the life sciences. Advanced degree preferred.
  • Industry Experience: 10-15+ years of relevant biopharmaceutical industry experience, including mid to late-stage clinical development and execution of registrational and/or Phase 3 clinical trials. Experience with cell and gene therapy and oncology drug development preferred, but not required.
  • Program Management: 7-10 years of program management experience in a fast-paced, innovative biotech/pharma company.
  • Technical Proficiency: Expert knowledge of business and project planning software, including experience integrating new software platforms into organizations.

Interpersonal Skills

  • Leadership: Strong interpersonal skills with the ability to motivate others, build relationships and trust, influence without authority, and navigate conflict situations.
  • Curiosity and Proactivity: A curious and proactive nature.
  • Collaboration: Highly collaborative team player who fosters open and honest communication and facilitates mutual understanding and cooperation between all stakeholders.
  • Communication: Proven ability to distill complex plans across multiple programs into intuitive, simple, and clear communication to facilitate prioritization and resourcing.
  • Motivation and Detail Orientation: Independently motivated, detail-oriented, and excellent problem-solving ability.
  • Adaptability: Thrive in dynamic, scientifically driven cross-functional environments.

Please note this position is located onsite in our Cambridge, MA office.

By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.

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