New

Senior Clinical Business Operations Manager

Boston, MA

Join Us in Tackling Autoimmune Disease at Its Root

At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.

When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care.

Why Work at Vor?

Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.

Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.

Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.

Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.

 

Who we are looking for: 

As the Clinical Business Operations Manager at Vor Bio, you play a pivotal role in supporting the Clinical Operations organization to successfully execute clinical studies within Vor Bio's growing portfolio. This position requires a blend of financial acumen, contract management expertise, program management skills, and a deep understanding of clinical trial operations. You work closely with cross-functional partners such as Program Management, Finance, and Legal on a regular basis to help bridge the gap between Finance, Accounting, and Clinical Operations to improve contracting and change order management, accruals, analysis, and forecasting.

This role oversees several critical areas within Clinical Operations to support the success of our studies, each of which is outlined in more detail below.

Clinical Finance:

  • Support scenario planning, budget development, tracking, and reporting for clinical trials, ensuring adherence to approved budgets and alignment with study objectives.
  • Provide the accurate reporting of study level financial accruals on monthly basis.
  • Produce study level and cross-project re-forecasts, budgets, and ad-hoc analysis.

 Contract Management:

  • Track work orders, change orders and change notifications on a timely basis.
  • Negotiate contracts with clinical trial vendors, CROs, and other relevant service providers.
  • Support STLs and others with PO setup and track approval/signature progress against target sign-off dates.

Clinical Sourcing Strategy and Vendor Relationship Management:

  • Develop and execute strategic plans alongside Clinical Operations for sourcing clinical trial vendors, ensuring alignment with organizational goals.
  • Evaluate and identify clinical trial service providers through comprehensive assessment and negotiation processes and provide recommendations.
  • Identify potential risks related to clinical sourcing, finance, and contracts and develop mitigation plans.
  • Stay abreast of industry trends and regulatory changes impacting clinical trial financial management.

 

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

  • Advanced degree in finance, business, life sciences, or related field.
  • Minimum of 8 years of experience in clinical sourcing, clinical finance, and contract management within the pharmaceutical or biotech industry required.
  • Strong financial acumen and deep knowledge of CRO and clinical vendor contracts, with experience in budgeting and forecasting for clinical trials.
  • Proven success in negotiating contracts and managing vendor relationships.
  • In-depth knowledge of clinical trial operations and regulatory requirements.
  • Exceptional communication skills with the ability to collaborate across cross-functional teams.
  • Leadership experience, with the ability to mentor and develop junior staff.
  • Ability to thrive in a fast-paced, dynamic environment and adapt to changing priorities while continuing to deliver high quality, professional work products.
  • Ability to create presentations and have solid presentation experience.
  • Experienced in Excel and tracking/forecasting systems.
  • Available for domestic and international travel.

 

At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well-being so you can thrive at work and beyond.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.

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