New

Senior Manager, Program Management and Drug Substance Lead

Boston, MA

Join Us in Tackling Autoimmune Disease at Its Root

At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.

When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care.

Why Work at Vor?

Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.

Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.

Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.

Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.

 

Location: Boston, MA preferred

We are seeking a Senior Manager, Program Management & Drug Substance Lead to support execution of drug substance development and manufacturing programs for biologics. This role combines program management with hands-on understanding of CHO-based manufacturing to ensure activities are well-coordinated, risks are proactively managed, and supply aligns with clinical and commercial needs. 

You will play a key role in advancing programs through late-stage development by working across internal teams and external partners to deliver reliable, scalable drug substance supply. 

 

 Roles and Responsibilities 

Program Management & Execution: Drive day-to-day program execution across drug substance activities. Develop and maintain integrated timelines, track deliverables, risks, and dependencies, and ensure alignment across CMC, Quality, Regulatory, Clinical, and Supply Chain teams. 

Drug Substance Development & Manufacturing: Support drug substance activities for biologics, including CHO cell line–based processes. Contribute to process development, tech transfer, scale-up, and manufacturing readiness. Partner with technical teams to ensure processes are robust, scalable, and aligned with program timelines. 

External Manufacturing Coordination: Coordinate activities across CDMOs and external partners. Track manufacturing progress, ensure deliverables meet expectations, and escalate risks or issues as needed. Support preparation for manufacturing campaigns and monitor execution. 

Supply Planning Alignment: Partner with Supply Chain to align drug substance manufacturing with clinical and commercial demand. Support planning activities, including production scheduling, inventory tracking, and risk mitigation for supply continuity. 

Risk Management & Issue Resolution: Identify program and technical risks and support development of mitigation plans. Work cross-functionally to resolve manufacturing, process, or supply issues in a timely manner. 

Cross-functional Collaboration: Coordinate across Quality, Regulatory, Clinical, Commercial, and Finance teams to ensure alignment on priorities, timelines, and deliverables. Support regulatory documentation and ensure consistency of CMC information. 

Program & Data Management: Maintain program plans, trackers, and dashboards using tools such as Smartsheet. Ensure timelines, risks, and decisions are accurately captured and communicated through clear updates and reporting. 

 

 Skills and Competencies 

Program Execution: Strong ability to manage timelines, track deliverables, and drive execution in a fast-paced environment. 

Technical Foundation: Working knowledge of biologics drug substance development, including CHO cell culture, upstream and downstream processes. 

Cross-functional Collaboration: Ability to work effectively across teams and manage competing priorities. 

Problem Solving: Strong analytical mindset with the ability to identify risks and support practical solutions. 

Communication: Clear and organized communicator, able to provide concise updates to stakeholders. 

 

Education, Experience and Qualifications 

Bachelor’s degree in life sciences, engineering, or related field; advanced degree preferred 

6–10+ years of experience in biologics drug substance development, manufacturing, or CMC program management 

Experience with CHO cell-based manufacturing systems required 

Working knowledge of upstream (cell culture) and downstream (purification) processes 

Experience supporting tech transfer, scale-up, and manufacturing execution 

Experience working with external manufacturing partners (CDMOs) 

Strong program management and data management skills; experience with tools such as Smartsheet preferred 

 

 

The salary range for the Senior Manager, Program Management and Drug Substance Lead is expected to be between $155,000 and $175,000 per year.  Individual pay may vary based on multiple factors including but not limited to relevant job-related skills, experience, education or training, market factors, and work location.

 

At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well-being so you can thrive at work and beyond.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.

Create a Job Alert

Interested in building your career at Vor Bio? Get future opportunities sent straight to your email.

Apply for this job

*

indicates a required field

Resume/CV

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Select...
Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Vor Bio’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.