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Director, Protein Science

Lexington, MA

About Voyager Therapeutics

Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of – and ultimately cure – neurological diseases. Our pipeline includes programs for Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; Neurocrine Biosciences, Inc.; and Sangamo Therapeutics, Inc. For more information, visit www.voyagertherapeutics.com.

Voyager Therapeutics® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc. 

Job Summary

Voyager Therapeutics is seeking an experienced Director of Protein Science to join our growing Non-Viral Team. The ideal candidate will establish, build, and lead a Protein Science group to support the discovery and development of our brain delivery platform and associated expansion of the biologics pipeline. As a leader in the Research organization, the Director of Protein Science will be responsible for setting a strategy that ensures protein sciences capabilities align with leading technologies to facilitate platform and program advancement. Reporting to the Vice President of Non-Viral Delivery, this role is an opportunity to build a group that will make foundational contributions to Voyager’s growth in non-viral delivery.

Key Responsibilities

  • Drive the development and implementation of a strategy to bring critical infrastructure and capabilities in-house to support protein production, purification, and analytics
  • Lead the design and build out of lab space to meet the expanding needs of the Protein Science group
  • Recruit and mentor a team of highly skilled scientists to design, express, purify and characterize a diversity of protein candidates
  • Contribute to the achievement of critical platform and program goals by delivering high quality proteins and reagents
  • Develop a scalable molecular biology workflow enabling engineering and high-throughput protein production
  • Identify, establish, and manage relationships with contract research organizations (CROs) to provide scalable access to critical expression, purification, and analytic capabilities
  • In collaboration with Data Sciences, develop a structural biology workflow to provide mechanistic insights into candidate molecules
  • Develop and manage timelines, resources and operating budgets

Qualifications

  • PhD in biochemistry, biophysics, chemical engineering or related field with 10+ years of industry experience
  • Demonstrated leadership experience with a track record of building and growing cross functional teams
  • A strong background in protein expression across a diversity of platforms, including high-throughput expression systems, is desired
  • Deep expertise in a range of chromatographic separation techniques for antibody and protein purification
  • Extensive expertise in biochemical and biophysical characterization of proteins and protein complexes
  • Prior experience managing contract research organizations (CROs) for the production, purification and characterization of proteins is a plus.
  • Outstanding analytical, research and organizational skills
  • Self-motivated with an ability to handle multiple projects, meet deadlines and make decisions
  • Excellent oral and written communication skills

 

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