Sr. Research Associate I, Biology
About Voyager Therapeutics
Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of – and ultimately cure – neurological diseases. Our pipeline includes programs for Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; Neurocrine Biosciences, Inc.; and Sangamo Therapeutics, Inc. For more information, visit www.voyagertherapeutics.com.
Voyager Therapeutics® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc.
Job Summary:
We are seeking an experienced and highly motivated biologist to contribute to our biochemical and in vivo research team at our facility in Lexington, Massachusetts. This is an ideal position for an individual with an in vivo biology background and biochemical/molecular biology methods, who thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech environment. The individual will work at the bench on multiple projects and be responsible for experimental execution and data analysis for research studies supporting therapeutic programs and platform discovery research. We are looking for prior hands-on experience with protein purification, ELISA, western blot, mouse handling, perfusion and tissue collection.
Primary Responsibilities:
- Support of rodent in vivo experiments, animal handling, and test article dosing via various administration routes (IP, IM, IV etc). Experience with stereotactic brain surgery is preferred
- Rodent perfusion, necropsy, dissection, and tissue collection including serum & CSF collection
- Ex vivo tissue analysis (tissue processing, protein purification, ELISA, western blot, RT-qPCR, etc.), DNA isolation, and independent data analyses
- Experience in In vitro cell culture and transfection, as well as in imaging
- Closely collaborate with research scientist to execute in vivo studies utilizing rodent models to support AAV-based gene therapy research and development for neurodegenerative diseases.
- Perform biochemical and tissue-based assays to support project development and target validation
Requirements:
- A minimum of a Bachelor’s degree with 5+ years’ experience or a Master’s degree with 2+ years’ experience or equivalent in neuroscience, cell culture, biomedical sciences, animal sciences or related discipline
- Outstanding problem-solving skills
- Understanding of biological safety and animal welfare practices and regulations
- Self-motivated, trustworthy, and ability to be highly productive in a fluid, collaborative, and fast-paced team environment
- Outstanding problem-solving skills
- Experience with design, documentation, and execution of experiments
- Ability to be highly productive in a fluid and fast-paced work environment
- Scientific and team-directed communication skills
- Must be organized and efficient in processing samples and performing analyses on a consistent schedule
Strongly Preferred:
- Experience with animal handling
- Experience on cross-functional therapeutic program teams
- Experience within a start-up or small biotech environment
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