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Senior/Principal Research Associate, In Vivo

Lexington, MA

About Voyager Therapeutics

Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of – and ultimately cure – neurological diseases. Our pipeline includes programs for Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; Neurocrine Biosciences, Inc.; and Sangamo Therapeutics, Inc. For more information, visit www.voyagertherapeutics.com.

Voyager Therapeutics® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc. 

Job Summary:

We are currently seeking an experienced and highly motivated Senior/Principal research associate who shares our passion for the promise of neurogenetic medicine. The successful candidate will work with our multidisciplinary team in Lexington, Massachusetts. This is an ideal position for an individual with a strong background in preclinical rodent in vivo experiments, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.

The individual will design and execute hands-on in-house rodent studies to support platform and discovery research. The successful candidate will interact with cross-functional Neuroscience Research program teams to execute in vivo pharmacology and efficacy studies using non-viral and gene therapy approaches. The candidate will analyze data and communicate study progress and data through presentations and reports.

Key Responsibilities:

  • The individual will be responsible for experimental design, execution and data analysis for research studies supporting platform and discovery research
  • Design and hands-on execute rodent in vivo experiments including experiments in animal models of neurodegenerative disease
  • Performing test article dosing via various administration routes (e.g. IV, brain stereotactic infusions), brain and tissue collection, and downstream analysis (e.g. RT-qPCR, bDNA, western blot and ELISA)
  • Performing data analyses and delivering data presentation to teams
  • Ensuring maintenance of industry-quality records and proper documentation
  • Monitor health, perform behavioral assessments and tissue/blood collection

Qualifications

  • A Master’s degree with a minimum of 6 years of experience or a Bachelor’s Degree with a minimum of 8 years of experience is required
  • A minimum of 6 years of hands-on experience with performing test article administration in rodent (mouse and rat) is required
  • Experience in neuroscience is required
  • Technical proficiency with a wide variety of rodent in vivo pharmacology skills (IV, IP, stereotactic delivery)
  • Conducting ex vivo tissue analysis (i.e. Digital ELISA, RT-qPCR, etc) preferred
  • Outstanding problem-solving skills and ability to multi-task
  • Self-motivated, able to work independently, highly organized with strong attention to detail

*Position level determined by candidate experience, qualifications, and competencies

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