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Senior Scientist, Antibody Discovery and Protein Engineering

Lexington, MA

About Voyager Therapeutics

Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of – and ultimately cure – neurological diseases. Our pipeline includes programs for Alzheimer’s disease, Friedreich’s ataxia, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; and Neurocrine Biosciences, Inc. For more information, visit http://www.voyagertherapeutics.com.

Voyager Therapeutics® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc. 

Job Summary:

Voyager Therapeutics is seeking a highly motivated Senior Scientist*, Antibody Discovery and Protein Engineering to join our growing Non-Viral Therapeutics Team. This is an exciting opportunity to contribute to the development of next-generation brain delivery platforms and therapeutic programs. The ideal candidate will play a key role in engineering and optimizing antibody-based modalities using advanced display technologies and library screening approaches. This role requires strong cross-functional collaboration with Protein Science, Neuroscience, and Bioinformatics to drive innovation in CNS targeted biotherapeutics.

Position Specific Responsibilities:

  • Lead the development and optimization of display platforms (phage and yeast) for antibody and protein engineering applications
  • Design, build and screen diverse immune and synthetic antibody libraries including monoclonals, antibody fragments, nanobodies and other novel antibody modalities
  • Apply strategies for antibody affinity maturation and functional optimization
  • Implement and refine high throughput screening workflows, including FACS, NGS and deep mutational scanning
  • Analyze data to identify lead molecules and guide engineering decisions
  • Collaborate with cross-functional teams, including Protein Science, Neuroscience, and Bioinformatics to advance platforms and therapeutic candidates
  • Stay current with advances in protein/antibody engineering and display technologies
  • Contribute to patent filings, publications, and external presentations

Specialized Knowledge, Skills, & Qualifications:

  • PhD in biochemistry, protein engineering, chemical engineering or related field
  • 5+ years of hands-on industry experience using display technologies
  • Proven expertise in yeast and phage display platforms, as exemplified by a strong publication record
  • Track record of success in antibody discovery, from immunization to library design, hit selection, humanization, and optimization
  • Experience with immune and/or synthetic library generation and screening
  • Proficiency with standard molecular biology techniques and protein expression systems
  • Outstanding analytical, research and organizational skills
  • Self-motivated with an ability to handle multiple projects, meet deadlines and make decisions
  • Excellent oral and written communication skills

*Position level determined by candidate experience, qualifications, and competencies

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