Back to jobs

Principal/Senior Principal Translational Computational Biologist

About the Role

We are seeking a Principal Translational Computational Biologist to connect structure-based design with drug development. This role is responsible for establishing pipelines to collect and curate antibody/biologics sequence, structural, and functional datasets and liaising with the design teams to enable model refinement and generation through specific analyses. In that capacity, they will act as both a platform builder and as a key member of multiple therapeutics project teams.

About You

You are an expert in analyzing antibody/biologics sequences and structures, as well as in the optimization of potential candidates to enable lead generation. 

Key Responsibilities 

  • Conceive, execute, and communicate computational analyses of antibody/biologics sequences and structures in combination with a wide range of assay information to guide large molecule drug development.
  • Collaborate with experimentalists to evaluate and extend computational tools and create efficient pipelines for the analysis of assay, multi-omic, and structural data in the context of large-molecule drug development.
  • Collaborate with colleagues to design and execute wet-lab experiments that will enable informative computational analyses.
  • Design and execute computational analysis in accordance with best-in-class scientific standards and software development practices to ensure robust, reproducible results.
  • Communicate complex computational concepts and results to non-expert stakeholders.

Minimum Qualifications

  • Experience establishing efficient pipelines for the analysis of high-throughput screening data from antibody and other large molecule drug development programs.
  • Experience with analysis of a range of assay data in a drug development context, including binding (e.g., SPR), display experiments, and developability assays (e.g., viscosity and aggregation).
  • Experience with structure and sequence analysis in the context of large-molecule drug development, including integration of screening information with experimentally determined structures and computational models.
  • Experience with relevant genomic and transcriptomic analyses for large molecule drug development.
  • Ability to write high-quality analytical code both independently and as part of a team.
  • Excellent oral and written communication skills. Ability to communicate complex concepts to audiences with a wide range of backgrounds and technical familiarity.
  • Ability and desire to work in a fast-paced interactive environment.
  • PhD in Biology, Bioinformatics, Bioengineering, Computer Science, or equivalent. 
  • 5-8 years of experience post-PhD expected.

Preferred Qualifications

  • Prior pharmaceutical or biotechnology industry research and development experience desired.

Compensation

The specific compensation package for this role depends on experience, qualifications and level. We anticipate the compensation range to be $170,000 to $300,000 per year. 

Xaira Therapeutics is an equal opportunity employer. We thrive on diversity and collaboration, and we welcome candidates with diverse backgrounds and experiences. 

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf


Education

Select...
Select...
Select...

Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Xaira Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.