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Sr. IT Security & Infrastructure Program Manager

South San Francisco, California, United States

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

At Xaira, we are seeking a highly motivated, experienced, and dependable IT Security & Infrastructure Program Manager to join our fast-moving and execution-driven team. This role requires a strategic and detail-oriented professional who is passionate about security, compliance, and infrastructure management.

As a key member of our team, you will collaborate with cross-functional stakeholders—both technical and non-technical—as well as external consultants to plan, execute, and oversee the full lifecycle of security and infrastructure projects. You will play a pivotal role in evaluating, developing, and operationalizing Xaira’s security and compliance programs to meet evolving regulatory and business needs.

Key Responsibilities

  • Lead cross-functional teams through full program lifecycles, from defining scope and success criteria to execution, implementation, and performance evaluation.
  • Build and maintain strong working relationships across security, IT, compliance, and infrastructure teams to ensure alignment with business objectives.
  • Scope, plan, implement, and deliver security and infrastructure projects, working closely with senior leaders to support strategic goals.
  • Manage and drive compliance audits (e.g., SOC 2 Type II, GDPR, ISO 27001/27701, HIPAA) from initial planning to completion, ensuring adherence to industry standards.
  • Act as the security subject matter expert (SME) to lead compliance initiatives and help remove barriers to achieving compliance objectives.
  • Oversee end-to-end security and infrastructure programs, from evaluation and design to implementation and process optimization.
  • Work closely with auditors to plan, scope, execute, and manage security and compliance audits.
  • Provide expertise in security domains such as authentication, endpoint security, encryption, cloud security, and data protection.
  • Collaborate with internal teams to enhance security posture, streamline operations, and drive process improvements.
  • Communicate effectively with both technical and non-technical stakeholders, ensuring clarity and alignment across teams.

Qualifications

  • Bachelor’s degree in Computer Science, Information Security, Management Information Systems, or a related technical field.
  • 10+ years of experience in IT security program management and infrastructure project management.
  • Deep understanding of at least one or more security frameworks (e.g., SOC 2 Type II, GDPR, ISO 27001/27701, HIPAA) and the ability to design and implement compliant security controls.
  • Proven experience leading and managing IT security and infrastructure projects from inception to completion, including process evaluation, optimization, and execution.
  • Hands-on experience across multiple IT functions, including security engineering, IT operations, infrastructure, and vendor management.
  • Strong knowledge of security best practices, covering areas such as authentication, encryption, endpoint security, cloud security, and data protection.
  • Exceptional project management and prioritization skills, with the ability to handle multiple initiatives simultaneously.
  • Excellent communication and collaboration skills, with the ability to engage effectively with both technical and non-technical stakeholders.

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $150,000 - $185,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. XairaTherapeutics is not responsible for any fees related to unsolicited resumes.

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