Scientist, Cell Pharmacology

Waltham, MA

Scientist, Cell Pharmacology

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment. Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.).

SUMMARY: 

The Scientist, Cell Pharmacology is a member of the Cellular Pharmacology group and will support Xilio’s growing immuno-oncology pipeline. Reporting to the Associate Director, Cell Pharmacology, this key role offers the opportunity to directly contribute to Xilio’s cutting edge immuno-oncology programs by developing assays and generating decision-making data. This role provides an exciting opportunity to directly influence ongoing programs and contribute to the discovery of new drugs to treat cancer patients.

Job Responsibilities:

  • Work as an integrated member of the research team to generate data to support ongoing drug discovery efforts.
  • Serve as expert on cell-based assays to support discovery and development programs.
  • Research relevant literature to devise cellular functional experiments. Implement and execute cell-based assays such as phenotypic assays and reporter gene assays (RGA), which assess drug candidate activity and mechanism of action.
  • Develop assays to characterize and analyze protease activity in different biological samples, including measurement of substrate cleavage kinetics to support understanding of protease activity in human disease.
  • Prepare dissociated cell suspensions from fresh human tumor tissues to understand molecule function in the context of cancer.
  • Develop and run ligand binding assays.
  • Perform gel electrophoresis and western blot assays to assess recombinant proteins.
  • Capture detailed experimental information and data analyses in electronic lab notebook (ELN) entries.
  • Represent Cell Pharmacology at project team meetings.
  • Provide assay development expertise to support manufacturing sciences, non-clinical DMPK, and Tox studies.

Skills, Qualifications, and Requirements:

  • PhD in Biology, Cell Biology, Biochemistry or similar subject with 0-1 years biotech/ pharma experience or BS/MS in Biology, Cell Biology, Biochemistry or similar subject with 4+ years (BS) or 2+ years (MS) biopharma experience.
  • Mammalian cell culture experience is essential.
  • Technical experience in the development, qualification, and execution of cellular phenotypic assays is highly preferred.
  • Previous experience with FACS, ELISA, and MSD-based readouts.
  • Prior experience working with proteases is a plus.
  • Experience with Western blots, CE-SDS, and recombinant proteins.
  • Generation of genetically engineered cell lines and/or experience with CRISPR is a plus.
  • Goal oriented, organized, capable of working on multiple projects, and able to execute to timelines that meet company goals.
  • Willing to learn new techniques and skills.
  • Work well in a cross-functional team environment, both independently as well as being willing to help others.
  • Excellent verbal and written communication skills.

Equal Opportunity and Inclusion

Our human capital resources objectives include, as applicable, identifying, recruiting, retaining, incentivizing and developing our existing and additional employees. We are committed to equal opportunity and inclusion across all aspects of our organization, including in our recruitment, advancement and development practices. We conduct annual performance and development reviews for each of our employees to discuss the individual’s strengths and development opportunities, career development goals and performance goals. We also regularly survey employees to assess employee engagement and satisfaction. In addition, each regular full-time employee is provided an allowance and time to attend appropriate job-related trainings and other professional development courses, seminars, meetings, and similar sessions. If you are an individual with a disability who requires an accommodation with the hiring process, please reach out to careers@xiliotx.com.

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