Senior Scientist/Principal Scientist, Biotherapeutic Engineering

Waltham, MA

Senior Scientist/Principal Scientist, Biotherapeutic Engineering

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment. Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.).

SUMMARY: 

We are seeking a highly skilled and experienced Sr Scientist/Principal Scientist in Biotherapeutics Engineering to design and optimize biologics-based drugs, incorporating structural biology expertise and molecular biology methods. The successful candidate will have a strong background in structural biology, protein engineering and antibody discovery workflows. A background in applying machine learning techniques and molecular modeling to improve the biophysical and biological properties of biotherapeutics is desired. The candidate is expected to have expertise in leading cross-functional teams, generating key data, and driving projects from in silico concepts to in vivo proof of concept (PoC).

Job Responsibilities:

  • Design and generate complex biologics and various multi-specific formats for preclinical therapeutic validation.
  • Analyze protein structures to rationally design biologics.
  • Perform biochemical and biophysical characterization of designed/engineered proteins to examine protein function as well as identify and develop structure-function relationships.
  • Support antibody discovery and in house yeast/phage display
  • Apply state-of-the-art in silico biotherapeutic engineering tools, CCG-MOE or Schrodinger-Maestro and/or others, to design and optimize biologics-based drugs.
  • Lead or co-lead research project team, accountable for defining project strategy, ensuring effective execution of activities to meet project goals and timelines.
  • Represent Protein Engineering at project team meetings.
  • Support writing and reporting of key experiments in IND filings.
  • Capture detailed experimental information in electronic lab notebook (ELN) entries.

Skills, Qualifications, and Requirements:

  • BS/MS or PhD in Biochemistry, Structural Biology, Chemical and Biomolecular Engineering or a related field with 8-15 years (BS/MS) or 3-9 years (PhD) of relevant post-graduate experience in industry setting.
  • Strong expertise in biotherapeutics design, engineering, and molecular biology is required.
  • Strong analytical and problem-solving skills for computational analysis of protein and DNA sequences are required.
  • Background in structural biology is strongly preferred.
  • Experience with biophysical characterization of biological molecules including SPR is strongly desired.
  • Knowledge of yeast/phage display and antibody discovery is a plus.
  • Familiarity with electronic lab notebooks (such as Benchling) for data mining and analysis is desired.
  • Experience with CRO project management is highly preferred.
  • Excellent leadership and communication skills to effectively lead cross-functional teams and collaborate with stakeholders is required.
  • Excellent organizational skills, with the ability to multi-task in a fast-paced environment with changing priorities.

Equal Opportunity and Inclusion

Our human capital resources objectives include, as applicable, identifying, recruiting, retaining, incentivizing and developing our existing and additional employees. We are committed to equal opportunity and inclusion across all aspects of our organization, including in our recruitment, advancement and development practices. We conduct annual performance and development reviews for each of our employees to discuss the individual’s strengths and development opportunities, career development goals and performance goals. We also regularly survey employees to assess employee engagement and satisfaction. In addition, each regular full-time employee is provided with an allowance and time to attend appropriate job-related trainings and other professional development courses, seminars, meetings, and similar sessions. If you are an individual with a disability who requires an accommodation with the hiring process, please reach out to careers@xiliotx.com.

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