Manager, Digital Architect

Waltham, MA

Manager, Digital Architect

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment. Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.).

SUMMARY: 

We're seeking a Manager, Digital Architect to join our growing IT team and help shape the future of technology at Xilio. This role is ideal for an emerging technology leader who thrives on variety, loves solving complex problems, and wants to make a meaningful impact across all aspects of our technology ecosystem. You'll work directly with our CIO in a collaborative, fast-paced environment where your contributions will directly enable scientific breakthroughs.

This position balances strategic thinking with hands-on execution across four core areas that define modern IT excellence. You'll have the opportunity to grow your management skills while building expertise in cutting-edge technologies that support life sciences innovation.

Job Responsibilities:

  • Projects & Strategic Development (30%)
    • You'll take ownership of technology initiatives from conception to completion, transforming innovative ideas into practical solutions that advance our mission. This includes:
      • Leading and supporting cross-functional technology projects that support research, clinical, and business operations
      • Evaluating emerging technologies and determining their potential value for our organization
      • Building custom solutions when commercial options don't meet our unique needs
      • Managing project timelines, stakeholder communications, and deliverable quality
      • Translating complex technical concepts into accessible language for diverse audiences
      • Collaborating with department leaders to identify technology needs and opportunities
      • Creating project documentation and post-implementation assessments to drive continuous improvement
  • Operations & Infrastructure (20%)
    • You'll ensure our technology foundation is robust, secure, and scalable to support our growing organization. This includes:
      • Monitoring and maintaining critical systems including cloud environments, networks, and security infrastructure
      • Managing vendor relationships and technology procurement decisions
      • Ensuring compliance with industry regulations and security best practices
  • Process & Innovation (20%)
    • You'll drive continuous improvement by identifying opportunities to enhance efficiency through technology:
      • Researching and implementing automation solutions that eliminate manual, repetitive tasks
      • Exploring artificial intelligence and machine learning applications for business processes
      • Designing and optimizing workflows that improve productivity across departments
      • Building proof-of-concept solutions to validate new approaches before full implementation
  • Employee Experience & Service (30%)
    • You'll be a technology advocate and problem-solver for our team, ensuring everyone has the tools and support they need to excel:
      • Providing technical support and troubleshooting for hardware, software, and connectivity issues
      • Managing employee technology lifecycle from onboarding through offboarding
      • Creating training materials and conducting sessions on new tools and best practices
      • Developing self-service resources that empower users to resolve common issues independently
      • Gathering feedback and implementing improvements to enhance the overall technology experience
      • Leading incident management and resolution processes
      • Building relationships across departments to understand and anticipate technology needs

Skills, Qualifications, and Requirements:

What We're Looking For

  • Leadership & Growth Mindset
    • You're in your first management role or ready to take on management responsibilities for the first time
    • You have a history of demonstrating strong problem-solving abilities and can work independently on assigned projects
    • You're comfortable with ambiguity and can prioritize effectively among competing demands
    • You're passionate about mentoring others and helping them succeed with technology
  • Technical Foundation
    • You have a broad technology background with the ability to learn new platforms quickly
    • You understand fundamental concepts of networking, security, data management, and system integration
    • You're comfortable with both cloud and on-premises environments
    • You have experience with automation tools and understand the principles of good data architecture
    • You can code or script when needed, but more importantly, you understand when technology solutions are appropriate
  • Industry Awareness
    • You understand the unique compliance, security, and operational requirements of regulated industries
    • You're familiar with the challenges of supporting scientific research and development environments
    • You appreciate the importance of data integrity, audit trails, and validation in life sciences
  • Communication & Collaboration
    • You excel at translating technical concepts for non-technical stakeholders
    • You're genuinely excited about technology's potential to solve business challenges
    • You approach every interaction with a service-oriented mindset
    • You're comfortable presenting ideas and recommendations to leadership
  • Curiosity & Adaptability
    • You bring extraordinary energy to your job and love technology and helping others
    • You're genuinely curious about new technologies and enjoy continuous learning
    • You're not intimidated by unfamiliar platforms or tools
    • You can quickly assess whether a new technology might benefit our organization
    • You balance innovation with practical implementation considerations

Why You'll Love This Role

  • Direct impact on life-saving cancer research through technology innovation
  • Opportunity to work with cutting-edge technologies in a supportive environment
  • Variety in daily work across strategic, operational, and service areas
  • Professional development support and encouragement to pursue new skills
  • Collaborative culture where your ideas and contributions are valued
  • Small team environment where you can make a significant difference

Equal Opportunity and Inclusion

Our human capital resources objectives include, as applicable, identifying, recruiting, retaining, incentivizing and developing our existing and additional employees. We are committed to equal opportunity and inclusion across all aspects of our organization, including in our recruitment, advancement and development practices. We conduct annual performance and development reviews for each of our employees to discuss the individual’s strengths and development opportunities, career development goals and performance goals. We also regularly survey employees to assess employee engagement and satisfaction. In addition, each regular full-time employee is provided an allowance and time to attend appropriate job-related trainings and other professional development courses, seminars, meetings, and similar sessions. If you are an individual with a disability who requires an accommodation with the hiring process, please reach out to careers@xiliotx.com.

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