Director, Bioanalysis
Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC® Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC® targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.
In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling: vepdegestrant for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer; ARV-102 for the treatment of patients with neurodegenerative disorders, and ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas.
In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC® androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024.
#TeamArvinas is made up of approximately 280 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.
For more information, please visit www.arvinas.com.
Position Summary
We have an exciting opening for a seasoned bioanalytical scientist with expertise in the area of small molecule bioanalysis. The incumbent will contribute as a bioanalytical expert supporting drug discovery through all stages of drug development, with a focus on regulated bioanalysis for nonclinical GLP programs and clinical programs.
This position reports to the Vice President Nonclinical Sciences and can work with a hybrid or remote work arrangement from a location within the United States.
Principal Responsibilities
Key responsibilities of this role include, but are not limited to:
- Contribute to the formulation and execution of bioanalytical strategy supporting all facets of Arvinas bioanalytical needs from a project, portfolio, or functional levels.
- Participate in the non-regulated bioanalytical support for in vitro ADME, preclinical in vivo PK, ADME, and PK/PD studies, DRF toxicology studies and regulated and GLP-compliant bioanalytical work for GLP toxicology and clinical pharmacology.
- Contribute to bioanalysis outsource strategy; evaluate, recommend, or select bioanalytical CROs to ensure timely and stage-appropriate bioanalytical support of Arvinas projects.
- Serve as Arvinas SME and oversee the development, qualification, or validation of bioanalytical methods for various matrices and species
- Serve as Arvinas representative to coordinate all facets of bioanalysis and ensure timely delivery of high-quality bioanalytical results to support project progression and decision-making.
- Ensure high quality and regulatory compliance for all Arvinas regulated bioanalytical work.
- Stay up to date with the scientific advance and evolving domestic (FDA) and international (ICH, etc.) regulatory landscape for bioanalysis for the pharmaceutical industry.
Qualifications
- 10+ years of direct experience in bioanalysis in the biopharmaceutical industry or CROs supporting pharmaceutical development, with a focus on small molecules
- Expertise on LC/MS/MS based bioanalytical science including theoretical background and practical problem-solving skills
- Previous experience with ligand binding assays and immunogenicity assays to support biological and ADC development highly desirable
- In-depth knowledge of current regulatory requirements and up-to-date knowledge of evolving regulatory landscape for GLP bioanalysis
- General knowledge of drug discovery and development process.
- Experience in bioanalytical outsourcing
- Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without a need for a current or future VISA sponsorship.
- The duties of this role are generally conducted in a combination of company office and home office environments. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.
Education
- Ph.D. in chemistry, pharmaceutical science, or related scientific discipline preferred.
- Master’s Degree with an equivalent combination of education and experience.
#LI-Remote
Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com
Arvinas is an Equal Opportunity Employer
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