Postdoctoral Fellow, Humanized Mouse Models

Biohub is leading the new era of AI-powered biology to cure or prevent disease through its 501c3 medical research organization, with the support of the Chan Zuckerberg Initiative.

The Team

The Chan Zuckerberg Biohub New York (CZ Biohub NY) (https://www.czbiohub.org/ny/) is an independent nonprofit research institute that brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. CZ Biohub NY itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision                                                                     

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at CZ Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

The van der Stegen Lab at Biohub NY is looking for a Postdoctoral Fellow to develop a humanized mouse model to study human immune cell development and engineering through in vivo gene perturbation. You will establish human immune cell generation through engraftment of (pluripotent stem cell-derived) hematopoietic stem and progenitor cells, and you will design a CRISPR/Cas engineering strategy to facilitate in vivo perturbation screens. You will be based at the Biohub NY and work closely together with our partners at Yale University.

The role requires the ability to work in a collaborative, multi-disciplinary environment and a drive to design and establish new research tools. 

Interested candidates should submit the following documents:

• Cover letter indicating your research experience, interests and career goals
• Full Curriculum Vitae
• Contact information for 3 references

What You'll Do

• Conduct independent and collaborative research.
• Design, perform, and analyze experiments.
• Established engineered mouse models.
•  Establish bone marrow chimeras.
• Design CRISPR/Cas engineering strategies and library screens.
• Prepare manuscripts for publication in peer-reviewed journals.
• Follow advances in the field through published literature and conferences.
• Present your work internally and externally at conferences.
• Work closely with fellow team members and external collaborators.

What You'll Bring

Essential - 

• PhD degree in immunology, developmental biology, molecular biology, genetics, biochemistry, or a related field
• Confidence with hands-on animal handling
• Minimum of 2 years of experience working with cloning, molecular biology and gene editing
• The ability to conduct experiments independently
• Demonstrated ability to work in a collaborative environment
• Strong drive to perform cutting-edge research
• Excellent verbal and written communication skills

Nice to have - 

• Hands-on experience in animal surgeries
• Experience with flow cytometry, microscopy and in vivo imaging techniques
• Experience with the production of viral vectors
• Strong knowledge on the existing literature in immunology and genetic engineering
• Experience working with pluripotent stem cells

Compensation

The New York, NY base pay this role is $93,000.00. 

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs.
• Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving to the Bay Area

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

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