Specialist/Senior Specialist, Immunohistochemistry

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

The Immunohistochemistry Specialist/Senior Specialist will be central to advancing our drug development pipeline. This is a fast paced highly collaborative position which will be key to speeding medicines to patients. You will work cross functionally supporting pre-IND candidates through late-stage development collaborating with internal and external partners.

Responsibilities

• Perform routine microtomy and staining of single/multi-plex Immunohistochemistry and RNA-ISH.
• Independently design, develop, guide, troubleshoot and validate IHC assay development for lead candidate molecules.
• Source, procure, and inventory FFPE tissue blocks for project and banking needs.
• Use a comprehensive electronic notebook and inventory system to record specimens, reagents, and experimental details.
• Perform full slide scanning maintaining an image and slide inventory system
• Maintain laboratory supplies and reagents. Participate in general lab upkeep.

Data analysis and interpretation:

• Independently and with supervision interpret, understand and communicate complex scientific data to guide rapid decision making.
• Leverage expertise to enable decision making within team and cross-functionally.

Project collaboration:

• Operate independently and collaboratively within cross-functional teams to design, plan and execute experiments aimed at advancing drug development projects.
• Partner and collaborate with colleagues from diverse scientific disciplines, including chemistry, pathology, biomarker, pharmacology, and translational medicine to rapidly achieve project goals.
• Collaborate with facilities and EHS to ensure optimal functionality of our lab space and adherence to safety guidelines.
• Fearlessly represent IHC team in project team meetings.

Documentation and reporting:

• Maintain meticulously detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions.
• Prepare and present research findings to internal cross-functional teams and contribute to project updates providing histology and assay expertise.

Continuous learning and development:

• Readiness and excitement for exploring new avenues and developing new assays in a fast-paced environment.
• Stay informed about the latest advancements in techniques for evaluating targeted therapeutics.
• Proactively seek opportunities for professional development.
• Contribute to and support the scientific growth of the research team.

Qualifications

• Bachelor’s degree in a life sciences field.
• Minimum of 5 years of extensive experience performing histology and assay development in a drug discovery setting including multi-target and multi-species assays in preclinical drug development.
• Certified histotechnician (HT) or histotechnologist (HTL) highly desired.

Knowledge and Skills

• Experienced immunohistochemistry assay development scientist.
• Familiarity with several IHC platforms including BondRX along with general IHC core instrumentation.
• Ability to prioritize and balance multiple projects simultaneously.
• Previous experience in antibody-based therapeutics or oncology drug discovery is preferred.

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).