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National Sales Director, Metabolics

US Remote

MISSION

Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously.

POSITION SUMMARY 

The National Sales Director is a second-line field leader responsible for driving commercial performance, building high-performing Area Business Director (ABD) teams, and ensuring execution excellence across the Metabolics portfolio. This role translates national strategy into area and regional impact, with a strong emphasis on rare disease expertise, patient-centricity, and cross-functional leadership.

JOB FUNCTIONS/RESPONSIBILITIES

Business Leadership

  • Own and deliver national business performance across the Metabolics portfolio
  • Develop and execute product business plans aligned to national strategy
  • Analyze market trends, competitive dynamics, and performance data to inform actions

Team Leadership & Development

  • Lead, coach, and develop first-line leaders to maximize team effectiveness
  • Build a strong leadership pipeline and succession plans
  • Foster a culture of accountability, engagement, and continuous improvement

Execution Excellence

  • Ensure consistent and high-quality execution of brand strategy in the field
  • Monitor KPIs and drive disciplined performance management
  • Identify and scale best practices across regions

Cross-Functional Collaboration

  • Partner with Marketing, Market Access, Medical Affairs, Patient Services and Operations
  • Ensure alignment of strategy and coordinated execution
  • Provide field insights to inform brand planning and lifecycle strategy

Market & Customer Engagement

  • Maintain strategic relationships with key opinion leaders (KOLs) and top accounts
  • Understand regional nuances in referral patterns and treatment pathways
  • Support teams in navigating complex access and reimbursement environments

Compliance & Ethical Leadership

  • Ensure all activities comply with regulatory, legal, and company policies
  • Model integrity and patient-first decision making
  • Reinforce a culture of compliance across the organization

QUALIFICATIONS

Education/Experience:

  • Bachelor’s degree required; MBA or advanced degree preferred
  • Minimum 7 years pharmaceutical/biotech experience, with 5+ years of leadership experience
    • Successful experience leading leaders (second-line leadership) highly desired
    • Significant rare disease and/or specialty experience
    • Proven success in product launches, ideally with first-in-class therapies and in competitive markets
    • Demonstrated ability to build, lead, train and develop high-performing teams
    • Proven success in sales leadership roles with the ability to inspire, influence and align teams
  • Experience navigating complex rare disease patient journeys, including diagnosis, referral pathways, and difficult access to therapies
  • Strong leadership presence with the ability to inspire, influence, and align teams
  • Strong understanding of market access, payer dynamics, and patient services
  • Demonstrated ability to lead in a matrixed organization
  • High integrity, ethical standards, and commitment to compliance
  • Thrives in a fast-paced, dynamic, and collaborative environment
  • Able to travel frequently, up to 60% overnight travel and has a valid drivers’ license

The salary range for this position is $303,188 to $377,064 USD. Compensation will be determined based on several factors including, but not limited to; skill set, years of experience, and the employee’s geographic location. Please note that the required compensation details listed in US role postings reflect the base salary only, and do not include bonus, equity, or benefits unless otherwise provided.

#LI-REMOTE

Mirum Pharmaceuticals is committed to Equal Employment Opportunity (EEO) and to compliance with all Federal, State and Local laws that prohibit employment discrimination on the basis of race, age, national origin, ethnicity, religion, gender, gender identity, pregnancy, marital status, sexual orientation, citizenship, genetic disposition or characteristics, disability, veteran’s status or any other classification protected by applicable State/Federal/Local laws.

Mirum Pharmaceuticals provides reasonable accommodation for qualified individuals with disabilities and disabled veterans in job application procedures.

 

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