Sr Medical Director, Clinical Development

US Remote

At Natera, we are transforming the future of personalized medicine. Our Therapeutics & Innovations (T&I) business sits at the forefront of this mission, advancing novel therapeutics that redefine standards of care for patients worldwide. We are seeking a visionary Senior Medical Director, Clinical Development to join this high-impact team. Reporting directly to the Head of T&I, this role provides a unique opportunity to shape Natera’s therapeutic pipeline from discovery through late-stage clinical development. The successful candidate will be a seasoned leader who thrives at the intersection of science, clinical strategy, and regulatory innovation.

The Opportunity
This is a career-defining leadership role with enterprise-wide visibility. As Senior Medical Director, you will:

  • Own the strategic direction and execution of clinical and pre-clinical programs, ensuring alignment with both Natera’s long-term vision and near-term milestones.
  • Be the face of T&I’s clinical development programs, engaging directly with global regulators, academic collaborators, CROs, and key opinion leaders.
  • Build and mentor a high-performing clinical development team, fostering a culture of excellence, accountability, and innovation.
  • Partner with world-class scientists, bioinformaticians, and R&D leaders across oncology, immunology, and precision medicine to translate breakthroughs into transformative therapies.

Key Responsibilities

  • Lead end-to-end planning, execution, and oversight of clinical trials and pre-clinical studies.
  • Design innovative and scientifically rigorous clinical trial protocols, ensuring regulatory compliance and ethical standards.
  • Drive development of critical documents including clinical development plans, target product profiles, and regulatory submissions.
  • Present clinical strategy and outcomes to executive leadership, advisory boards, and external stakeholders, positioning Natera as a thought leader in precision therapeutics.
  • Oversee CROs, academic collaborations, and cross-functional partners to ensure seamless and timely program delivery.
  • Engage directly with regulatory agencies (FDA, EMA), leading submissions such as INDs, CTAs, and other key filings.
  • Manage budgets, timelines, and risk-mitigation strategies to ensure milestones are met with excellence.

Qualifications

  • Advanced degree required (PhD, PharmD, or equivalent); MD strongly preferred.
  • Minimum of 10+ years in clinical and/or pre-clinical development within biotech or pharma.
  • Proven track record of advancing therapeutic candidates from early-stage through late-stage clinical development.
  • Deep expertise in clinical trial design, regulatory strategy, and cross-functional program leadership.
  • Strong executive presence with exceptional communication, organizational, and leadership skills.

Preferred Experience

  • Oncology, immuno-oncology, or precision medicine drug development.
  • Biomarker-driven trial design and translational medicine.
  • Experience leading global trials and cross-functional collaborations with academic partners and CROs.
#LI-TH1 #LI-Remote
The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA

$268,600 - $340,000 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents. 

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

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