Fall 2025 Co-op: Analytical Development, mRNA Drug Substance

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Co-op Assignment Overview

Prime Medicine is seeking a co-op for the Fall 2025 cycle to join the analytical development (AD) team. The candidate will gain valuable hands-on experience with a variety of laboratory techniques such as HPLC and capillary electrophoresis, collaborate cross-functionally with process development and quality control teams, and assist in the development of novel separation-based methods to solve complex analytical challenges and advance the pipeline. There will be also many valuable opportunities to learn about the scientific and regulatory requirements of in vivo and ex vivo gene editing therapeutic drug development, and participate in projects that are crucial to the success of Prime Medicine.

Primary Responsibilities:

• Perform a variety of assays to support companywide analytical needs for the analysis of drug substance components such as mRNA and drug products such as LNP
• Under guidance, execute method development with separation-based methods to characterize drug substance and drug product
• Document experimental data meeting analytical development requirements in electronic notebooks and present findings at team meetings
• Effectively communicate with team members and other groups including process development, quality control, and laboratory operations

Qualifications:

• B.S. or M.S. candidate in biochemistry, chemistry, chemical engineering, or a related field.
• Basic knowledge of separation sciences and technologies, with an understanding of the fundamental principles behind biological and chemical techniques
• Ability to work independently and collaboratively as needed
• Excellent organization, documentation, and communication skills, with the aptitude to handle multiple projects in a fast-paced environment
• Skilled in writing comprehensive reports of laboratory activities and ensuring proper inventory of consumables, reagents, and analytical equipment
• Independently motivated and detail-oriented, with the ability to identify and solve technical issues

Preferred Qualifications:

• Hands-on experience with separation-based analytical techniques such as HPLC and capillary electrophoresis
• Experience working in a process development, analytical development, quality control, and/or GxP environment
• Understanding of cell and gene therapy within the biotechnology industry

What We Offer:

• A cutting-edge team open to mentorship and networking.
• Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
• Participation in regular seminars with industry experts.
• Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.