Fall 2025 Co-op: Cell Therapy Process Development

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Co-op Assignment Overview

Prime Medicine is seeking a highly motivated co-op for the Fall 2025 cycle with strong hands-on laboratory experience in cell biology, chemical engineering, or bioengineering to join the Cell Therapy Process Development (Cell PD) team. This position is ideal for candidates who want to contribute by executing laboratory experiments who have an interest in cell therapy process development and/or ex vivo gene editing. 

The candidate will play a key role in developing and characterizing a cell therapy manufacturing process involving prime editing of primary human cells. This lab-based role involves conducting process development experiments, troubleshooting, and performing sample characterization. The position offers the opportunity to work in a fast-paced, collaborative setting across multiple departments gaining exposure to bioprocessing technology, in process analytical techniques, ex vivo gene editing, and hematopoietic stem cell biology.   We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.

Primary Responsibilities:

• Hands-on execution of process development experiments, including thorough documentation, data analysis, and data presentation.  
• Prepare, verify, and support experimental setup for cell therapy process development runs. 
• Perform real-time sample characterization using techniques such as cell counting, flow cytometry, and biochemical assays.  
• Contribute to troubleshooting of process unit operations. 
• Compile, analyze, and interpret experimental data, providing clear and insightful presentations/reports to the team.  

Qualifications:

• Must be enrolled in the undergraduate/advanced degree program at the time of Co-op program.
• Hands-on experience with aseptic techniques and mammalian cell culture required.
• Strong wet lab skills with a demonstrated ability to execute experiments independently. 
• Proficiency in data analysis tools (i.e., Excel, Prism, MATLAB, R) for experimental interpretation.
• Meticulous attention to detail with strong documentation and organizational skills. 
• Team-oriented mindset, but also able to work independently. 
• Excellent verbal and written communication skills.
• A passion for learning and contributing to multiple facets of a program.

Preferred Qualifications:

• Student currently at least a junior pursuing a BS, or student enrolled in MS degree. 
• Experience with cell-based and/or molecular biology assays.
• Familiarity with bioprocessing principles.
• Previous, undergrad academic research and/or co-op and internship industrial experiences in biotechnology.
• Strong problem-solving skills and ability to troubleshoot experimental challenges
• Highly motivated with strong desire to learn new processes and techniques.

What We Offer:

• A cutting-edge team open to mentorship and networking.
• Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
• Participation in regular seminars with industry experts.
• Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.