Fall 2025 Co-op: Hematology and Immunology

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Co-op Assignment Overview

Prime Medicine is seeking a Fall 2025 co-op with a background in cell and molecular biology to join our Hematology and Immunology team. This role provides a unique opportunity to work hands-on in a collaborative, fast-paced environment contributing to screening and validation of Prime Editing strategies across our hematological and immune-related indications.

As a part of this role, you will gain valuable technical skills in cell and molecular biology while developing a deep understanding of gene editing, hematopoietic stem cell (HSC) biology, and human immune cell function. The position will involve work on both HSCs and human immune cells, contributing to innovative research with potential therapeutic applications.

We are looking for curious problem-solvers who thrive in a collaborative team environment and are passionate about advancing gene editing technologies for the treatment of human diseases.

Primary Responsibilities:

• Cell Culture & Functional Assays
• Perform primary human cell culture using aseptic technique
• Conduct program-specific cell-based functional assays, including flow cytometry
• Process in vivo samples for downstream analysis
• Molecular Biology & Gene Editing
• Extract genomic DNA, perform PCR, and prepare samples for next-generation sequencing
• Assist in Prime Editing experiments and downstream molecular analysis
• Data Analysis & Collaboration:
• Design and plan experiments with scientific rigor
• Analyze and interpret data, contributing to team discussions
• Present findings in team meetings

Qualifications:

•  B.S. candidate in Cell & Molecular Biology or a related major
•  Basic understanding of cell and molecular biology
•  Strong teamwork and communication skills
•  Scientific curiosity, attention to detail, and excellent record-keeping skills

Preferred Qualifications:

• Hands-on experience with aseptic technique and cell culture
•  Experience with basic molecular biology techniques (e.g., DNA extraction, PCR)
•  Interest in human disease research and motivation to help patients
•  Familiarity with flow cytometry or other immune-based assays

What We Offer:

• A cutting-edge team open to mentorship and networking.
• Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
• Participation in regular seminars with industry experts.
• Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.