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Scientist II, Flow Cytometry Resource Manager

Cambridge, MA

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Position Overview:
The Scientist, Flow Cytometry will serve as a technical expert focused on supporting flow cytometry across all therapeutic and functional areas at Prime Medicine. This individual will oversee the daily operation and maintenance of all flow cytometry cell sorters and analyzers and will provide expert technical support, training, and guidance to researchers across the entire Company, playing a critical role in ensuring high-quality data generation for drug discovery projects.  

Duties & Responsibilities:

  • Manages Core Instruments: Oversees daily operations of the core according to portfolio priorities, including scheduling, training, maintenance, and troubleshooting. 
  • Technical Expert: Provides hands-on expertise for instrumentation, assay development, and data analysis, supporting research teams in the design and execution of experiments.
  • Assay Development: Collaborates with internal research teams to design and develop complex multi-parameter assays, ensuring robustness, reproducibility, and alignment with project goals.
  • Collaborate & Consult: As a technical subject matter expert (SME), acts as a consultant for cytometry across the entire company, including pre-clinical, non-clinical, analytical development, and clinical. Consults on the design of methods, protocol optimization, and reagent selection.
  • Training and Mentorship: Trains and mentors scientists across the company in techniques, instrument use, data interpretation; fostering collaboration and innovation.
  • Innovation & Optimization: Remains current with evolving cytometry advances and their application to drug discovery; proactively looks for ways to improve workflows, integrate new technology and improve data quality.
  • Resource Management: Manages the maintenance/service contracts and consumables.
  • Electronic reporting: Develop and maintain ELN templates, protocols, and registries associated with flow cytometry and ensure user training and awareness. 

Qualifications:

  • B.S. 8+, M.S. 6+, PhD 2+ years of research experience in Immunology, Cell Biology, or related field. 
  • Must have a minimum 3 years of experience extensively operating BD FACS Aria series cell sorters, including independent instrument start-up, experiment set-up and sorting, preventative maintenance, creating custom configurations, and troubleshooting.  
  • Must have 3+ years of experience operating at least 2 of these analyzers: BD FACS Symphony (or LSR/Fortessa), Agilent Novocyte, or Thermo Fisher Attune. Familiarity with BD FACS Lyric and Sony SH800/MA900 sorter is a plus.
  • Minimum of 8 years demonstrated experimental expertise in cell-based assays with a focus in flow cytometry.
  • Demonstrated ability to develop and implement a diversity of flow cytometry assays and methods to support drug discovery programs.
  • Experience with biological cell sample processing relevant to flow cytometry, including working with whole blood, cell lines, and dissociated tissues.
  • Strong oral and written communication skills with the ability to work collaboratively and to communicate complex scientific concepts with cross-disciplinary teams, including to non-experts.
  • Preferred: Demonstrated experience supporting flow cytometry core operations. 

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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