Back to jobs
New

In Vitro Biochemist/Biophysicist

Framingham

Schrödinger seeks an In Vitro Biochemist/Biophysicist to join us in our mission to improve human health and quality of life through the development, distribution, and application of advanced computational methods.

As a bench scientist in the in vitro biology team with the Schrödinger Therapeutics Group, you’ll collaborate with scientists and drug developers who have experience with all common target classes and therapeutic areas. We’re supported by over 100 software developers and engineers, as well as a large-scale compute infrastructure to apply our proprietary physics-based drug design and optimization platform. Several of our programs have achieved development candidates, including progression to the clinic and FDA approval. You can view our entire pipeline of wholly-owned programs and collaborations here.

Who will love this job:

  • A self starter who has extensive experience with in vitro biology assay development and execution, plus an in depth knowledge of protein biochemistry, enzymology and biophysics
  • A creative collaborator who can multi-task and collaborate effectively
  • A results-oriented, self-motivated team player who’s skilled at working in a multidisciplinary environment
  • A dedicated scientist who’s comfortable working across a number of disease areas and able to shift gears quickly to advance drug discovery research
  • An excellent oral and written communicator who can accurately document scientific results according to best practices

What you will do:

  • Ideate, design and execute biochemical, biophysical and cell biology experiments in support of drug discovery projects 
  • Transfer optimized in vitro assays to CRO partners
  • Provide in vitro biology input to multiple program teams and help enable biochemical, biophysical and cell-based assay development for characterization and screening of NCEs
  • Manage CRO relationships to support, guide and troubleshoot biochemical, biophysical and cell-based experiments
  • Review, analyze and interpret in vitro data and troubleshoot issues related to drug discovery projects
  • Update the in vitro biology and program teams on active programs regularly

What you should have:

  • PhD in enzymology, biochemistry or a related field with 0-2 years relevant hands-on experience, or MS with at least five years of relevant experience in academia or industry
  • Expertise in establishing and troubleshooting in vitro biochemical/biophysical assays with experience in multi-mode assay platforms 
  • Hands-on experience in running binding and functional assays for compound screening and MOA studies 
  • Background in managing in vitro biology experiments for multiple drug discovery programs
  • Experience in Hit ID for drug targets in the undrugged space
  • Working knowledge of data analysis and statistical softwares e.g. GraphPad Prism, KinTech explorer 

We’d prefer to hire someone with:

  • Experience in handling cell cultures, and establishing and troubleshooting cell-based assays (e.g., CTG/MTT, Western blot, CETSA, ELISA and FRET/BRET assays)
  • Experience with biophysical methods such as SPR, ITC, and NanoDSF
Pay and perks:
Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have regular catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time.  Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces. 
 
Sound exciting? Apply today and join us!
 
As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Select...
Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Schrödinger’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.