Principal Biostatistician

Principal Biostatistician

Truveta is the world’s first health provider led data platform with a vision of Saving Lives with Data. Our mission is to enable researchers to find cures faster, empower every clinician to be an expert, and help families make the most informed decisions about their care. Achieving Truveta’ s ambitious vision requires an incredible team of talented and inspired people with a special combination of health, software and big data experience who share our company values.

Truveta was born in the Pacific Northwest, but we have employees who live across the country. Our team enjoys the flexibility of a hybrid model and working from anywhere.  In person attendance is required for one week during the year for Truveta Planning Week.

For overall team productivity, we optimize meeting hours in the pacific time zone. We avoid scheduling recurring meetings that start after 3pm PT, however, ad hoc meetings occur between 8am-6pm Pacific time. #LI-hybrid

Who We Need 

Truveta is rapidly building a talented and diverse team to tackle complex health and technical challenges. Beyond core capabilities, we are seeking problem solvers, passionate and collaborative teammates, and those willing to roll up their sleeves while making a difference. If you are interested in the opportunity to pursue purposeful work, join a mission-driven team, and build a rewarding career while having fun, Truveta may be the perfect fit for you. 

This Opportunity

We are seeking a Principal Biostatistician to join our team and play a key role in advancing the use of large language models (LLMs) in healthcare data analysis. In this role, you will be responsible for evaluating the performance of LLMs in extracting data from unstructured clinical documentation originating in electronic health record (EHR) systems, validating the accuracy and consistency of that data, and developing code and analytical tools that enable customers to seamlessly use the extracted outputs combined with other semi-structured data sources in their scientific studies.

The ideal candidate will combine strong statistical expertise with programming skills and a deep understanding of real-world data (RWD), data quality, and validation methods. You will collaborate closely with machine learning engineers, terminologists, clinical informaticists, and data scientists to ensure that model-derived data are both statistically sound and clinically meaningful. You will also interface with customers in order to help them understand the data, how it can be used, and its limitations. The ideal candidate is highly proficient in using real-world data and advanced statistical methods, and thrives in a collaborative, data-intensive environment.

Key Responsibilities

• Lead the design and execution of statistical evaluation strategies for Truveta’s AI and clinical models, ensuring rigor and reproducibility.
• Develop and apply advanced statistical methods to evaluate model performance, calibration, generalizability, and bias, especially in the context of real-world data (RWD).
• Guide the use of observational study designs and causal inference techniques to strengthen model evaluation using RWD.
• Partner closely with clinical, data science, and product teams to define evaluation criteria that align with clinical relevance, patient outcomes, and regulatory standards.
• Provide expertise on data quality, missingness, confounding, and heterogeneity in RWD to ensure robust evidence generation.
• Communicate statistical insights and evaluation results effectively to technical teams, clinicians, external stakeholders, and research collaborators, influencing model improvement, validation, and adoption.
• Stay current with evolving best practices in biostatistics, machine learning evaluation, and RWD methodologies, and mentor teams on their application.

 Required Skills

• Master’s or Ph.D. in Biostatistics, Mathematics, Epidemiology, Health Economics, Data Science, or related field.
• 7+ years of applied statistical experience with EHR and/or claims data (e.g., Optum, MarketScan, Flatiron, Epic, Oracle Health (formerly Cerner), CMS).
• Strong programming skills in R and SQL; experience with Python, PySpark, or Databricks a plus.
• Proven expertise in working with structured health data using medical ontologies such as ICD-10, CPT, NDC, LOINC, SNOMED CT, and RxNorm.
• Experience with statistical methods to evaluate:
• Performance metrics such as precision, recall, F1 score
• Agreement and Reliability
• Error and Bias
• Robustness
• Strong communication skills (written and verbal)

Preferred Qualifications

• Experience supporting regulatory-grade Real World Evidence (RWE), Health Outcomes, or payer-facing studies.
• Exposure to clinical phenotyping, NLP, or unstructured data integration.
• Ability to translate statistical output into clinically meaningful insight.
• Proactive communicator, comfortable working across teams and customers. Strong documentation habits and commitment to reproducibility.

Why Truveta?   

Be a part of building something special. Now is the perfect time to join Truveta. We have strong, established leadership with decades of success. We are well-funded. We are building a culture that prioritizes people and their passions across personal, professional and everything in between. Join us as we build an amazing company together.  

We Offer:

• Interesting and meaningful work for every career stage
• Great benefits package
• Comprehensive benefits with strong medical, dental and vision insurance plans
• 401K plan
• Professional development & training opportunities for continuous learning
• Work/life autonomy via flexible work hours and flexible paid time off
• Generous parental leave
• Regular team activities (virtual and in-person as soon as we are able)
• The base pay for this position is $190,000 to $215,000. The pay range reflects the minimum and maximum target. Pay is based on several factors including location and may vary depending on job-related knowledge, skills, and experience. Certain roles are eligible for additional compensation such as incentive pay and stock options.

If you are based in California, we encourage you to read this important information for California residents linked here.

Truveta is committed to creating a diverse, inclusive, and empowering workplace. We believe that having employees, interns, and contractors with diverse backgrounds enables Truveta to better meet our mission and serve patients and health communities around the world. We recognize that opportunities in technology historically excluded and continue to disproportionately exclude Black and Indigenous people, people of color, people from working class backgrounds, people with disabilities, and LGBTQIA+ people. We strongly encourage individuals with these identities to apply even if you don’t meet all of the requirements.

Please note that all applicants must be authorized to work in the United States for any employer as we are unable to sponsor work visas or permits (e.g. F-1 OPT, H1-B) at this time. We appreciate your interest in the position and encourage you to explore future opportunities with us.