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Senior/Clinical Trial Manager (CTM)

Boston, MA

Join Us in Tackling Autoimmune Disease at Its Root

At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first- and potentially best-in-class dual BAFF/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.

When you join Vor, you’re not just working on a medicine. You’re part of a mission to redefine the future of autoimmune care.

Why Work at Vor?

Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.

Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.

Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.

Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.

 

 

Who we are looking for: 

Vor Biopharma is seeking a Clinical Trial Manager/Sr. Clinical Trial Manager who will be responsible for leading all aspects of clinical trial management from study start through study closure. 

Key areas of responsibilities: 

  • Manage all clinical aspects of a clinical trial and ensures trial execution in compliance with ICH/GCP guidelines/regulations and applicable SOPs 
  • Lead and collaborate effectively with cross-functional teams to oversee the setup, execution, and management of Vor Biopharma complex clinical trials according to plan and in the highest quality standards 
  • Can multi-task in a fast-paced environment with changing priorities and maintain accurate forecasts, clinical trial budgets, and timelines 
  • Assist in development and management of study budget and maintains it within financial goals; reviews and approves clinical invoices against approved budget 
  • Use operational and therapeutic expertise to optimize trial setup, implementation, and execution  
  • Proactively anticipate/identify study risks and issues, determine escalation pathway, and develop and implements solutions   
  • Conduct project risk analysis and develops risk mitigation strategies for a variety of complex problems to maintain study deliverables 
  • Provide technical expertise to oversee the development of clinical documents (protocol, informed consent form, CRF, monitoring plans, regulatory submission documents, clinical study report, investigator brochures, etc. 
  • Provide clinical operations expertise and strategic leadership in the evaluation, selection, and management of CROs and other external vendors to ensure successful clinical trial implementation and execution of Vor Biopharma clinical trials and ensure that performance expectations are met 
  • Provide expertise in the identification, engagement, and selection of key trial centers/PIs, as well as develop relationships with investigators and site staff 
  • Ensure audit-ready condition of clinical trial documentation and support inspection readiness activities 
  • Participate in the planning of quality assurance activities and coordinate resolution of audit findings, which includes management through resolution (CAPA) of any site or study level issues, deviations, etc. 
  • Actively provide direction and oversight and foster effective relationships with vendors, investigators, consultants, and colleagues 
  • Participate in the selection, training, and evaluation of study personnel (contract and internal) to ensure the efficient operation of the function 
  • Manage and mentor clinical team members, as needed 

Qualifications: 

  • BA or BS in a scientific, life science, or health-related discipline; advanced degree preferred  
  • CTM: Minimum of 5 to 7 years of experience in clinical research with 1-2 years managing trials in the biotech/pharma industry and/or prior CRO experience 
  • Sr. CTM: Minimum of 7+ years of experience in clinical research with at least 3-5 years managing trials in the biotech/pharma industry and/or prior CRO experience 
  • Experience in setup, execution, and oversight/operational management of hematology-oncology or relevant oncology trial experience 
  • Understand early phase/complex dose escalation or inpatient and/or transplant trial and cell therapy experience a plus 
  • Knowledge in how cell therapy, vein to vein, and supply chain processes work in complex oncology trials. 
  • Excellent communication, writing, and presentation skills with strong problem-solving ability and attention to detail 
  • Strong initiative and a can-do attitude, excellent organizational skills, ability to prioritize deliverables/tasks to meet deadlines, proven effectiveness in a fast-moving and growing biotech environment 
  • Solid working knowledge in Good Clinical Practices and ICH Guidelines and the application to the conduct of clinical trials 
  • Proficient in MS Office Suite, and understanding Clinical Trial Management System, eTMF, and EDC systems, is required  
  • Ability/willingness to travel both domestically and internationally, as required 

 

At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well-being so you can thrive at work and beyond.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.

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