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Scientist II/Sr. Scientist, In-Vivo Pharmacology

Lexington, MA

About Voyager Therapeutics

Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of – and ultimately cure – neurological diseases. Our pipeline includes programs for Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; Neurocrine Biosciences, Inc.; and Sangamo Therapeutics, Inc. For more information, visit www.voyagertherapeutics.com.

Voyager Therapeutics® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc. 

Job Summary:

We are seeking a highly motivated Scientist/Sr. Scientist to contribute to our Neuroscience team at our facility in Lexington, Massachusetts. This is an ideal position for an individual with hands-on experience supporting programs from initial in vivo target engagement, through in vivo pharmacology and proof of biology, to development candidate nomination. This individual would thrive in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment, while also being able to manage multiple projects and support the generation of compelling data to support Go/No Go decisions. Additionally, this person should have a strong ability to interpret the literature, and the data generated internally and followed by clear communication of any relevant information to the key stakeholders.

Position Specific Responsibilities:

  • Design and execute rodent in vivo experiments including target engagement, pharmacology and proof of biology studies.
  • Lead early rodent disease model validation studies needed to support the proof of biology evaluation of promising candidates
  • Conduct and manage all in-life activities, clinical observations and necropsies including dosing, blood or CSF collection, cage-side observations, body weight evaluation, perfusion, tissue dissection and collection.
  • Conducts ex vivo tissue, CSF and serum analysis (ELISA, western blot, RT-qPCR, etc.)
  • Manage external partners (CROs) to support data readouts for outsourced activities.
  • Performs data analyses independently as well as delivers effective data presentations to the research teams.
  • Ensures maintenance of industry-quality records to provide documentation.

Specialized Knowledge & Skills:

  • Outstanding problem-solving and organization skills
  • Ability to read and interpret the literature to support advancement of programs and/or platform discovery research.
  • Ability to be highly productive in a fluid and fast-paced work environment.
  • Good communication skills and ability to multi-task.
  • Ability to analyze and present data independently to the research teams.
  • Strong commitment to accountability for completion of projects in accordance with team and company plans.
  • Excellent organizational skill and attention to detail.
  • Thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.

Requirements:

Educational Requirements:

  • A PhD degree with 3+ years in the field of Neuroscience, Pharmacology or related discipline is required.

Experience:

  • Strong preference for a candidate with experience in AAV gene therapy.
  • Prior related experience, ideally with a biotechnology or other life sciences company, is preferred but not required.
  • Experience characterizing and utilizing disease rodent models to support target engagement and proof of biology studies.
  • Hands-on experience in dosing rodent models, CNS and peripheral tissue dissection, and downstream ex vivo analysis (RT-qPCR, western blot, and ELISA).
  • Generate and organize data obtained from all in vivo studies.
  • Prior experience in drug discovery for neurodegenerative diseases would be preferred.
  • Prior contract management experience is preferred but not required.

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