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Associate Director, Vector Production

Lexington, MA

About Voyager Therapeutics

Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of – and ultimately cure – neurological diseases. Our pipeline includes programs for Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; and Sangamo Therapeutics, Inc. For more information, visit www.voyagertherapeutics.com.

Voyager Therapeutics® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc. 

Job Summary:

Voyager Therapeutics is developing recombinant adeno-associated virus (AAV) vectors for treating neurological diseases. Robust and reliable vector production is central for establishing successful gene therapy applications. Voyager seeks a highly motivated scientist experienced with both AAV production and regulatory requirements to lead the vector production group. The head of vector production will oversee a team executing and establishing protocols involved in manufacturing preclinical grade rAAV. The ideal candidate for the Associate Director position will have experience in large-scale rAAV production, downstream processing, and product characterization. The successful candidate will have supervisory experience overseeing rAAV vector core staff and a track record of successful rAAV productions and analytics. This individual’s major responsibilities will be to lead a team to develop vector production and processing both in-house, at contract manufacturing organizations, to support preclinical programs and research. Extensive practical experience and expertise with AAV vectors, are necessary. The vector production group will function in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Voyager’s facility in Lexington, Massachusetts.

Requirements:

  • Degree in a biological science or chemical engineering (bioprocessing focus) with 7+ years of subsequent research experience
  • Minimum of 5 years' experience manufacturing AAV vectors
  • Minimum of 2 years' experience in supervisory role
  • Track record of successful research grade rAAV production runs
  • Significant experience with lead discovery/optimization
  • Supervised the production, QA and QC of rAAV used in preclinical studies
  • Outstanding organizational skills
  • Ability to be highly productive and flexible in a fluid and fast-paced work environment

Strongly Preferred:

  • Significant experience with early drug development within an industry (biotech or pharma) environment
  • Provided documentation to support IND filing
  • Working knowledge of neurobiology
  • Experience within a start-up or small biotech environment

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