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Scientist, Antibody Conjugation

Cambridge, MA

Overview

We are seeking a Scientist to join our Protein Sciences group to help with our antibody conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to work efficiently across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with a scientific background in antibody-drug conjugates including the assembly, purification, and analysis of these molecules.

This position is onsite and will be primarily located in Cambridge, MA.  

Key Responsibilities

Perform chemical reactions to assemble antibody-oligonucleotide conjugates using various conjugation handles, linkers, and antibody formats (IgG, Fab, scFv, bispecific)

  • Utilize multiple strategies for stochastic and site-specific conjugation
  • Optimize reactions and purification methods to improve yields and efficiency ranging from mg to gram scale
  • Independently troubleshoot conjugation reactions for improved yields and processes
  • Analyze conjugates using all relevant techniques (IEX, HIC, SEC, SDS-PAGE, mass spec, UV-Vis)
  • Understanding of antibody design and cloning is nice to have
  • Understanding of antibody ligand/target validation using BLI and SPR for kinetic analysis is nice to have
  • Drive automation for high-throughput conjugation at various scales
  • Work closely with biology teams to plan studies and generate materials on time for multiple projects
  • Proper electronic notebook record keeping with high attention to detail
  • Communication of experimental plans and data to multiple cross-functional scientific teams
  • Work closely with biologists, chemists, and pharmacologists to contribute to the strategic direction of research programs across multiple therapeutic modalities

Qualifications 

  • The candidate should have a PhD degree with 0-3 years of relevant experience
  • Strong understanding of antibody conjugation chemistries with both stochastic and site-specific techniques
  • Strong understanding of modern ADC chemistry and linker design highly preferred
  • Hands on experiences with preparing antibody-drug conjugates and analyzing them using multiple methods (IEX, HIC, SEC, mass spec)
  • 0-2 years of pharmaceutical or biotechnology industry experience is preferred
  • Experience with Agilent and AKTA software
  • Experience with recombinant protein analysis (affinity, size exclusion, reverse phase, hydrophobic interaction, ion exchange chromatography, SDS-PAGE, and UV-VIS spectroscopy)
  • Experience with SPR and/or Octet binding experiments is nice to have
  • Passionate about driving his or her projects to independently contribute to research directions and solve challenging issues
  • Detail oriented, self-motivated, and comfortable working with highly technical projects
  • Ability to work on multiple projects simultaneously and deliver conclusive results
  • Highly adaptable and responsive to new priorities in a fast-paced environment
  • Ability to train and supervise associate scientists in the laboratory
  • Effective written and oral communication skills
  • Experience with ELN record keeping
  • Experience preparing and presenting using PowerPoint software
  • Team oriented with strong work ethic

 

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.

The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

U.S. Pay Range

$110,400 - $165,600 USD

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