Back to jobs

Vice President, Immunology & Rheumatology – Clinical Development

South San Francisco, California

Work Location

Corporate Headquarters (South San Francisco, CA) Onsite – Hybrid

Non-local candidates will be considered

Position Summary

We are seeking an accomplished and visionary leader to join our team as Vice President, Immunology & Rheumatology – Clinical Development. The Vice President, Immunology & Rheumatology – Clinical Development play a critical role in shaping and executing our Immunology & Rheumatology strategies. In this role, the successful candidate will serve in a leadership role, helping set the direction of our efforts in classical complement-mediated autoimmune disease across the entire portfolio. In addition, the role will also be a member of the C1s Oral Small Molecule Core Team providing clinical and medical leadership in the overall strategy for that program, both in Phase 1 and Proof-of-Concept studies as well as later stages of development. Ultimately, the candidate would support the medical components of the submission, approval, and commercialization of drug candidates for the treatment of a range of autoimmune diseases. This role requires a seasoned professional with deep expertise in immunology and/or rheumatology as well as in drug development within this therapeutic area, possessing strong leadership skills and a track record of success in bringing innovative therapies to market. The Vice President, Immunology & Rheumatology – Clinical Development will be responsible for driving the clinical strategic direction of our ANX1502 program working collaboratively with key team leadership. Like all Annexon leaders, the Vice President, Immunology & Rheumatology – Clinical Development incumbent will have a deep-rooted commitment to serving patients and a passion for transforming the lives of people with serious diseases and their families.

Responsibilities

Drug Development:

  • Lead the medical/clinical oversight of the Phase 1 and Proof-of-Concept studies including: review and interpretation of clinical data and communication with sites.
  • Medical authorship and ensuring the integrity and quality of abstracts, manuscripts, study reports, and regulatory communications and documents, and site or safety (in collaboration with pharmacovigilance) communications.
  • Identify core objectives that lead to the design and implementation of the clinical development strategy and protocols to support the clinical development of drug candidates.
  • Support other members of the team representing the Medical function including medical monitoring, trial execution, and safety and tolerability determination.
  • Represent Annexon and ANX007 program for external engagements with CRO’s, consultants, sites, etc.
  • In collaboration with Clinical Operations and Medical, oversee the execution of clinical trials, ensuring compliance with regulatory requirements, ethical standards, and timelines as well as support for all medical monitoring activities.
  • Serve as the Immunology and Rheumatology leader for the development team, partnering closely with the Program Team Leader, heads of development operations, clinical operations, pharmacovigilance, clinical quality, and biostatistics.
  • Provide medical leadership for site selection, feasibility, enrollment, issue identification/resolution, and data quality.
  • Support for business development activities in Immunology.

Strategic Leadership:

  • Serve as a member of the C1s Oral Small Molecule Core Team and Development Leadership Team to support the creation and execution of a strategic plan for ANX1502 and its follow-on molecules, in collaboration with team members, the Program Team Leader, Translational Medicine, Research and functional leadership.
  • Partner with the Research function in considering aspects of drug discovery that could be leveraged into development programs.
  • Leverage scientific and clinical expertise to guide decision-making and optimize study design and execution.
  • Leadership role in collaboration with Medical Affairs for KOL engagement, Advisory Committee interactions, and Steering Team meetings.
  • Drive innovation and differentiation of drug candidates through the deep and complete understanding of current and future data generated for the program.
  • In collaboration with Regulatory Affairs and ANX1502 Program team, develop and execute robust regulatory strategies for the program.
  • Interface with regulatory authorities to facilitate successful regulatory submissions and approvals.
  • Stay abreast of evolving regulatory guidelines and requirements pertinent to immunologic drug development.

Cross-Functional Collaboration:

  • Foster strong collaboration and alignment across functions, including R&D, clinical development, Translational Medicine, regulatory affairs, commercial, and other relevant departments.
  • Serve as a key liaison between the Immunology team and executive leadership, providing regular updates on portfolio progress and strategic initiatives.
  • Cultivate a culture of teamwork, innovation, and accountability within the ophthalmology organization.

Requirements

  • Medical Degree and be board certified – Immunology and/or Rheumatology required.
  • Minimum of 15 years of experience in the pharmaceutical or biotechnology industry, with a focus on Immunology and Rheumatology drug development.
  • Proven track record of leadership in Immunology, including successful development and commercialization of Immunologic or Rheumatologic products.
  • In-depth understanding of immunologic diseases, drug development processes, and regulatory requirements.
  • Demonstrated ability to develop and execute strategic plans, drive innovation, and deliver results in a fast-paced, dynamic environment.
  • Strong leadership and interpersonal skills, with the ability to inspire and influence teams at all levels of the organization.
  • Excellent communication and presentation skills, with the ability to effectively articulate complex scientific and clinical concepts to diverse audiences.
  • Experience interacting with regulatory authorities and leading successful regulatory submissions and approvals.
  • Business acumen and strategic thinking, with a focus on maximizing the commercial potential of ophthalmology products.

 

Company Summary

Annexon Biosciences (Nasdaq: ANNX) is a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye. Annexon’s novel scientific approach targets upstream C1q to block the classical complement inflammatory cascade before it starts, and its therapeutic candidates are designed to provide meaningful benefits across multiple autoimmune, neurodegenerative and ophthalmic diseases. With proof-of concept data in Guillain-Barré syndrome, Huntington’s disease and geographic atrophy, Annexon is rigorously advancing its mid-to late-stage clinical trials to bring new potential treatments to patients as quickly as possible. To learn more visit annexonbio.com.

EEO Employer – Annexon highly values Diversity, Equity, Inclusion and Belonging

Annexon Biosciences is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment based on race, color, religion, national origin, age, gender, sex, ancestry, citizenship status, mental or physical disability, genetic information, sexual orientation, veteran status, or military status. We are proud to promote a work environment where everyone, from any background, can do their best work.

Staffing Agencies

Annexon Biosciences does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with Annexon Biosciences. Please do not send agency CVs/resumes through Annexon’s website or Annexon Employees.  Inquiries must be sent to  talentacquisition@annexonbio.com with the Subject Heading:  Staffing Agency Request.

 

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Select...
Select...


Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Annexon Bioscience’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.