Pharmacoepidemiologist, Causal Inference
(ID: 2024-6802)
Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).
Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Pharmacoepidemiologist, Causal Inference to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID).
Benefits We Offer:
- 100% Medical, Dental & Vision Coverage for Employees
- Paid Time Off and Paid Holidays
- 401K match up to 5%
- Educational Benefits for Career Growth
- Employee Referral Bonus
-
Flexible Spending Accounts:
- Healthcare (FSA)
- Parking Reimbursement Account (PRK)
- Dependent Care Assistant Program (DCAP)
- Transportation Reimbursement Account (TRN)
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).
We are seeking a talented Pharmacoepidemiologist to join our team to support projects at the NIH’s National Center for Advancing Translational Sciences (NCATS). In this role, you will collaborate with clinical and data scientists, methodologists, and software engineers to develop and execute exemplar causal inference studies. You will work as a subject matter expert to create a real-world evidence (RWE) methods decision tree; support master protocol development; and support development of gold-standard guides and methodologies for conducting best practices causal inference research. You will: design, execute, and analyze studies using the National Clinical Cohort Collaborative (N3C) data; review and recommend strategies for selecting study designs to answer causal inference questions; help establish, and implement appropriate analytic value sets.
The ideal candidate for the Pharmacoepidemiologist position is a highly skilled professional with a Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics, Causal Inference or related field. This person has experience with electronic health record and/or claims data and a strong understanding of observational study principles including: missing data handling methods; temporal research questions (cross-sectional, longitudinal); causal contrast of interest (e.g., intent-to-treat, per-protocol); effect measure of interest (e.g., risk ratio, hazard ratio); and estimands (e.g., average treatment effect, average treatment effect in the treated) of interest. Your research experience includes one or more of the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods, realized in multiple primary-author publications. Fluency with coding languages and tools is expected (i.e. SQL, Python, and R).
Responsibilities:
Serve as SME for RWE causal inference studies.
Design and execute studies with N3C EHR data considering the following: extent of missing data; missing data handling methods; temporal component of research studies (i.e. cross-sectional, longitudinal); the causal contrast of interest (e.g., intent-to-treat, per-protocol); the effect measure of interest (e.g., risk ratio, hazard ratio); and estimand (e.g., average treatment effect, average treatment effect in the treated) of interest.
Review and recommend strategies for selecting individuals in clinical cohorts.
Ensure the highest data quality and minimization of bias.
Use tools and languages such as Python, R, SQL, and Spark.
Help establish and implement appropriate analytic value sets.
Collaboratively produce extensive documentation (i.e. through training material, research protocols, open data sources such as repositories and/or methodological and research papers).
Work closely with data science and software developer teams to articulate technical methods and implement decision tool strategies.
Extract and transform clinical data from clinical trial and observational studies.
Participate in project meetings, provide updates on progress, challenges, and mitigation strategies.
Actively engage in key relevant meetings and keep abreast of emerging best practices and methods.
Qualifications
The ideal candidate:
Must have:
Ph.D. in Pharmacoepidemiology, Epidemiology, Biostatistics or related field.
Experience with the following: target trial emulation, sequential trial analysis, marginal structural models, longitudinal matching, G methods, or equivalent causal inference methods realized in at least 2 primary-author peer-reviewed publications, or equivalent.
Ability to independently conduct statistical analysis with analytic software tools (e.g. Python, R, SQL, MatchIt/WeightIt, Matplotlib, Lifelines, SKLearn, GT-summary, statsmodels, Survey).
Fluent in coding languages and tools (e.g. Python, R, SQL, Spark).
Strong communication and collaboration skills, with the ability to work effectively in a multidisciplinary team.
Nice to have:
Experience with meta-analyses and/or systematic reviews.
Expertise in best practices for statistical approaches, data wrangling and visualization.
Knowledge of FAIR data principles.
Clinical informatics experience.
Benefits
100% Medical, Dental, and Vision Coverage for Employees
Educational Benefits for Career Growth
Paid Time Off (including Holidays)
Employee Referral Bonus
Profit Sharing
401k matching
Flexible Spending Accounts:
Healthcare (FSA)
Parking Reimbursement Account (PRK)
Disclaimer:The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com
Salary Range
$90,000 - $120,000 USD
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