Sr. Scientist, DMPK

About GondolaBio

GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation.

About BridgeBio

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 20+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zurich, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://bridgebio.com

Who You Are

The primary responsibilities of this position are to serve as a DMPK representative on multi-disciplinary drug discovery teams, provide guidance and support to project teams for candidate selection, and further characterize the pharmacokinetic and drug metabolism properties of molecules through early development to IND. This individual will have the opportunity to be exposed to a broad spectrum of therapeutic areas across the portfolio.

Responsibilities

• Work closely with cross-functional project team members. Participate as a functional representative on discovery/early development project teams
• Provide guidance on discovery project teams for candidate selection, develop and drive DMPK strategies for lead optimization, and solve ADME-related issues
• Design, coordinate, and interpret in vitro and in vivo DMPK studies
• Determine PK parameters for nonclinical studies using Phoenix WinNonlin and assist with the application of modeling approaches (PK, PKPD) to support human PK and dose predictions
• Support GLP toxicology studies, review toxicokinetic reports, and monitor regulated bioanalysis
• Monitor bioanalytical method development, validation, sample analysis, and review/approve reports
• Generate, analyze and present data, both orally and as written reports

No matter your role at BridgeBio, successful team members are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

• PhD or Pharm D. in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on small molecule pharmacokinetics and metabolism with at least 3-5 years of relevant industry experience
• Strong understanding of DMPK principles and drug development processes
• Expertise in drug metabolism is desirable
• Hands-on experience using pharmacokinetic data analysis software such as Phoenix WinNonlin
• Able to work independently and possess excellent interpersonal skills
• Possess effective problem-solving, oral, and written communication skills

What We Offer

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• An unyielding commitment to always putting patients first. Learn more about how we do this here
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time 
• Partnerships with leading institutions
• Commitment to Diversity, Equity & Inclusion