Sr Scientist, Cell Biology

USA - South San Francisco, CA

Sr Scientist, Cell Biology (in South San Francisco)

Job Description

Programmable DNA, the software of Life, is finally here! Twist Bioscience is developing a disruptive, synthetic DNA technology that will change the world, enabling widespread health and sustainability. Synthetic biologists will use our products to engineer how organisms produce cures to diseases, make everyday chemicals by using the atmosphere as the carbon source, enable plants to make their own fertilizers, and to create in-vivo diagnostics that alert us when we are sick, and many more applications.

We are seeking a motivated, enthusiastic, and outstanding Senior Scientist, Cell Biology, to join our antibody discovery efforts.  This associate will play multiple roles within the Pharma group and will work within a team responsible for antibody discovery and characterization utilizing mammalian cell culture, HT FACS, and develop/execute HT functional cell based assays.

What You’ll Be Doing

  • Characterizing antibodies, VHHs or other binder formats in cell-based functional assays, including high-throughput formats of cytokine release assays, cell-based reporter assays, ligand binding studies, cAMP release, immunogenicity assays and MSD assays.
  • Perform high-throughput flow cytometry and FACS cell binding assays with antibodies against transiently transfected cell lines and stably expressed cell lines.
  • Establish target over-expressing cell lines for antibody discovery work
  • Understand and assess immuno-oncology signal transduction pathways via in vitro cell-based assays.
  • Strong background in cell culture and flow cytometry/FACS is required
  • Plan, perform, analyze, and document laboratory experiments in support of antibody discovery
  • Present your findings to both internal and external stakeholders
  • Evaluate and support the implementation of new technologies
  • Maintain laboratory instruments and logistics
  • Work collaboratively under aggressive timelines in a contract research setting

What You’ll Bring to the Team

  • Minimum of 2 years industry related work experience or relevant postdoc; with an educational background that includes a Ph.D. in cell biology, biochemistry, immunology, protein biochemistry, or related discipline
  • Have an understanding of antibody structure and function
  • You are excited to learn new techniques and work collaboratively with others
  • You thrive in a dynamic, quickly changing environment where we were work individually and on teams

Preferred Qualifications

  • Experience with ELISA-based detection of cytokines and other soluble factors from cell supernatant
  • Experience with molecular cloning to generate constructs to express proteins.
  • Ability to multitask and thrive in a fast-paced and challenging environment
  • Strong organization skills and proficiency in computer skills including various databases
  • Excellent oral/written communication and interpersonal skills a must
  • Experience in screening anti-GPCR antibodies in functional assays preferred
  • Experience expressing antibodies in HEK293/CHO and purifying them using traditional methods preferred
  • Excellent problem-solving capabilities
  • Extraordinary attention to detail and planning
  • Proficiency with Microsoft Word, Excel, and PowerPoint

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

San Francisco Bay Area Pay Range

$144,500 - $176,800 USD

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