Director, Functional Genomics

About the Role

We are seeking a visionary scientific leader to direct our Functional Genomics group, a critical driver of innovation at Xaira Therapeutics. This role will focus on pioneering and implementing high-throughput functional genomics platforms while leveraging advanced single-cell omics technologies. The successful candidate will spearhead technology development and collaboration with automation engineers, AI/ML scientists, computational biologists, and translational scientists to unlock novel insights into complex disease biology and therapeutic targets.

Key Responsibilities  

• Lead, manage and continue to build the Functional Genomics team to generate high-throughput perturbation data for drug discovery and AI/ML modeling initiatives.
• Continue to develop and implement advanced technologies, such as perturb-seq, CRISPRi/a, single-cell omics and advanced genetic engineering techniques, to drive functional genomics insights.
• Collaborate closely with AI/ML scientists, computational biologists, and disease biology experts to integrate large-scale data into predictive models.
• Design and optimize experiments using complex screening models, including cell lines, primary cells, differentiated cell types and in vivo systems.
• Drive technology innovation to streamline workflows, increase throughput, and enhance data quality in high-throughput perturbation assays.
• Oversee experimental design, protocol development, and resource allocation to ensure project milestones and scientific objectives are met.
• Present scientific findings and progress to internal and external stakeholders, contributing to publications, patents, and conference presentations.
• Mentor, train, and professionally develop research scientists and staff within the team.

Qualifications

• Ph.D. in molecular biology, genomics, bioengineering, or a related field with 10+ years of experience in functional genomics or genome engineering.
• Demonstrated expertise in CRISPR-based screening, perturb-seq, and single-cell RNAseq techniques.
• Proven track record in high-throughput data generation, processing, and interpretation for drug discovery or disease model development.
• Strong experience working with complex cellular models, including organoids and primary cell systems.
• Familiarity with AI/ML applications in functional genomics and experience collaborating with computational scientists.
• Effective leadership skills, with experience managing and mentoring high-performing research teams.
• Outstanding written and verbal communication skills for scientific presentations, reports, and publications.
• Ability to thrive in a fast-paced, collaborative research environment focused on scientific innovation and impact.

Compensation

The specific compensation package for this role depends on experience, qualifications and level. We anticipate the compensation range to be $174,000 to $230,000 per year. 

Xaira Therapeutics is an equal opportunity employer. We thrive on diversity and collaboration, and we welcome candidates with diverse backgrounds and experiences.