Sr. Scientist

About QED Therapeutics & BridgeBio Pharma

QED Therapeutics, an affiliate of BridgeBio Pharma, focuses on developing targeted treatments for FGFR-driven skeletal dysplasias, particularly Achondroplasia. Achondroplasia is the most common form of genetically-driven short stature, which causes potentially debilitating medical complications. With our experimental therapeutic candidate, infigratinib, we seek to provide an option to children living with Achondroplasia and their families.
 
Our business is inspired by our values:

• PUT PATIENTS FIRST
• LET SCIENCE SPEAK
• EVERY MINUTE COUNTS
• THINK INDEPENDENTLY
• BE RADICALLY TRANSPARENT

FGFR=fibroblast growth factor receptor.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, Raleigh, and with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://www.qedtx.com/ | https://bridgebio.com 

Who You Are

We seek a well-rounded, industry-trained in vitro and in vivo biologist to drive non-clinical pharmacology for skeletal dysplasia franchise. You will report into VP of Translational research. The role requires an in vitro pharmacologist with superior technical & problem-solving abilities, as well as excellent communication and interpersonal skills. This is an on-site role based in San Francisco Bay area. We hope to hear from you! 

Responsibilities

• Support pharmacology and biology of small molecule discovery programs 
• Initially, the primary responsibilities include hands-on execution of in vitro and cell-based assays and data analysis to support SAR work for small molecule lead identification and optimization 
• Responsible for rapid generation and accurate reporting of high-quality and reproducible data
• Collaborate with the medicinal chemistry team to drive design-make-test cycles
• Proper maintenance of laboratory notebooks and forms in accordance with company policies and practices. Routine maintenance, and upkeep of the laboratory 
• Eventually, the role will be expanded to include the design, execution, and management of broader pharmacology studies to support preclinical proof-of-concept (at external vendors) and IND submission.  
• Manage relationships with CROs for efficient execution of all the preclinical and translational studies. 
• Collaborate with cross-functional teams, including DMPK, toxicology, and regulatory to advance our therapeutic candidates from preclinical stages toward clinical development in a fast-paced, dynamic environment 
• Author study reports and pharmacology sections of regulatory documents including INDs 

No matter your role at BridgeBio, successful team members are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

• Ph.D degree in biology or pharmacology with 3+ years of related work experience in pharma or biotech environment is required 
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, and reporter cell lines 
• Excellent aseptic techniques and familiarity with principles of sterilization/disinfection
• Demonstrated ability to independently design, develop and optimize diverse cell-based assays and interpret complex results 
• Demonstrate strong proficiency in the design, execution, and evaluation of both colorimetric and fluorometric plate-based immunoassays such as ELISA and alphaLISA. 
• Ability to recognize and resolve technical and scientific problems independently or with support from other lab members  
• In vivo pharmacology expertise is highly desired, such as designing and executing animal models for skeletal dysplasia studies, knowledge of pharmacokinetics (PK) and pharmacodynamics (PD), ability to collect and analyze physiological data
• Strong scientific background and achievements in biological and translational sciences, ideally demonstrated by scientific publications, presentations, and/or patents
• Strong understanding of drug discovery and development processes  
• Excellent communication and organizational skills
• Demonstrate creative 'out of the box' thinking to solve complex technical problems and champion innovative technologies to achieve project goals 
• Commitment, drive, and ownership mindset 

What We Offer

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• An unyielding commitment to always putting patients first. Learn more about how we do this here
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time 
• Partnerships with leading institutions
• Commitment to Diversity, Equity & Inclusion